Abstract Focused ultrasound ablation is an emerging treatment for neurologic and psychiatric disorders. The ability to perform subthreshold sonications to evoke reversible clinical effects makes it suitable for functional neurosurgery….
Abstract Gene therapy, the delivery of therapeutic genes to the nervous system to restore function, represents a promising alternative approach for the treatment of neurologic disorders for which pharmacotherapy and…
Abstract Magnetic resonance imaging (MRI) has been utilized in the clinical setting for more than three decades. During this time, the technology has continued to evolve to improve image quality,…
Abstract Many advances have been made in the field of invasive brain–computer interface (BCI) technology in recent years, including improved implantable microelectrodes, better-performing neural decoding algorithms, and the development of…
Abstract This book chapter gives an overview of noninvasive brain–computer interfaces (BCIs) that replace, restore, enhance, supplement, or improve human functions. Each of the sections in the chapter is dedicated…
Abstract Persons with movement and communication impairment due to neurological injury can have function restored through brain–computer interfaces (BCIs) combined with appropriate prosthetic end effectors. Invasive BCIs record cortical activity…
Abstract The development of a stable intracortical recording electrode has tremendous implications for the rapidly expanding field of neuroprosthetics and, more broadly, brain–machine interfaces (BMIs). A variety of microelectrode designs…
Abstract Implanted brain–computer interfaces (iBCIs) have made impressive advances since the first human proof-of-concept demonstrations. Humans with long-standing paralysis have been able to communicate by typing at productive rates and…
Abstract This chapter focuses on neuromodulation systems that leverage feedback control to adjust stimulation properties automatically. Most current neuromodulation systems provide open-loop stimulation, wherein stimulation parameters are static and unaffected…
Abstract Implantable neurostimulators are the tools used by clinicians to execute the various and diverse neuromodulation therapies. Just as it is important for the engineers developing these stimulators to understand…
