Introduction The transsphenoidal route is a direct and rapid extracerebral approach to the sellar region and therefore it is the most widely used technique for the processes involving this area….
Introduction Prolactin-secreting adenomas or prolactinomas constitute the largest group of pituitary adenomas in an autopsy series. They are responsible for approximately 27% of pituitary tumors. In the advent of medical…
Introduction Intraoperative imaging has played a substantial role in the history of transsphenoidal surgery. Cushing’s discontinued his use of transnasal pituitary surgery mainly because of limited visibility during the operation….
Introduction Cushing’s syndrome is an endocrinopathy, resulting in distinctive clinical features and associated systemic changes. Cushing’s disease is the name given to the disorder when it is caused by a…
Introduction Radiotherapy has been successfully used for many decades to control tumor growth and hormonal hypersecretion of pituitary adenomas. Although initially used as a primary treatment for these neoplasms, in…
Introduction Primary pituitary carcinomas are rare tumors defined as primary adenohypophyseal neoplasms that have undergone cerebrospinal or systemic metastasis. They constitute 0.1% to 0.2% of all pituitary tumors and their…
Introduction Acromegaly is a medical condition defined by elevated serum growth hormone (GH) levels almost always secondary to hypersecretion by cells of the anterior pituitary. Descriptions of individuals consistent with…
Introduction The main purpose of this chapter is to provide a practical review of the visual and oculomotor manifestations of pituitary tumors. The close anatomical relationship between the pituitary gland…
Introduction The approach to tumors of the pituitary gland has undergone a developmental evolution during the past century. While Sir Victor Horsley performed the first transcranial approach to the pituitary…
Introduction Modern transsphenoidal approaches began with the contributions of Jules Hardy, who built on the legacy of earlier transsphenoidal approaches from Cushing’s to Norman Dott to Gerard Guiot. Hardy introduced…
