Spinal Cord Stimulation
CHAPTER 167 Spinal Cord Stimulation Oren Sagher, Emily Lehmann Since its development 40 years ago, spinal cord stimulation (SCS) has become an increasingly used treatment for chronic pain. In one…
Intrathecal Baclofen Therapy for Cerebral Palsy
CHAPTER 226 Intrathecal Baclofen Therapy for Cerebral Palsy Leland Albright Baclofen, chlorophenyl, cyclohexyl γ-aminobutyric acid, is a GABAB agonist originally synthesized for evaluation as an anticonvulsant. It was found to…
Dystonia in Children
CHAPTER 228 Dystonia in Children Leland Albright Definition and Pathophysiology Dystonia is an involuntary movement disorder characterized by sustained or intermittent muscle contractions that cause twisting and repetitive movements, abnormal…
Gene- and Viral-Based Therapies for Gliomas
CHAPTER 107 Gene- and Viral-Based Therapies for Gliomas Kaveh Asadi-Moghaddam, E. Antonio Chiocca Advances in understanding gene structure/function and in the capacity to manipulate their expression have set the stage…
Growth Factors in Glial Tumors
CHAPTER 101 Growth Factors in Glial Tumors Abhijit Guha, David Omahen This last part of surgery, namely, operations, is a reflection on the healing art; it is a tacit acknowledgement…
Neuroprosthetics
CHAPTER 94 Neuroprosthetics Jacob Aacob Donoghue, Jacob H. Bagley, Gerhard M. Friehs, Vasilios A. Zerris Hundreds of thousands of people are afflicted by injuries or disorders that disrupt input-output pathways…
Dandy-Walker Syndrome
CHAPTER 177 Dandy-Walker Syndrome Ondrej Choutka, Francesco T. Mangano History Dandy-Walker syndrome (DWS) represents a congenital malformation characterized by agenesis or hypoplasia of the cerebellar vermis, cystic dilation of the…
Pregnancy and the Vascular Lesion
CHAPTER 398 Pregnancy and the Vascular Lesion Khoi D. Than, B. Gregory Thompson, Jr. A cerebrovascular lesion in the setting of pregnancy presents a unique neurosurgical dilemma in which the…
Brain Tumor Immunology and Immunotherapy
CHAPTER 97 Brain Tumor Immunology and Immunotherapy Roberta P. Glick, Terry Lichtor, Amy B. Heimberger A Brief History of Immunotherapy About 1790, Jenner made the observation that milkmaids were protected…
Infectious Intracranial Aneurysms
CHAPTER 379 Infectious Intracranial Aneurysms Scott A. Meyer, Joshua B. Bederson The first description of an aneurysm of infectious etiology arising within the intracranial circulation was provided by Church in…
