Patient Perspectives
Worry and uncertainty prior to diagnosis Delays in diagnosis Relief and new worries when diagnosis is made Alarm about proposed brain surgery Value of talking to other patients Dependence upon…
Epidemiology
Prevalence (per 100,000 inhabitants) Geographical region Reference source 1.94 Japan Sakushima et al. (2012) 7 USA Kurtzke (1996) 8.2 New Zealand Brickell et al. (2006) 12.6 Tatarstan, Russia Authors’ data…
Pregnancy pregnancy
Is a normal vaginal delivery safe? Can a spinal or epidural anaesthetic be used? Are any offspring likely to be affected as well? 15.2 Pathophysiology Symptoms of Chiari develop as…
Clinical Presentation
Fig. 8.1 Origin of symptoms. This flowchart illustrates how both the syrinx and its underlying pathology combine to produce a variety of neurological symptoms (Courtesy of Graham Flint) 8.5 Differential…
Historical Aspects
Fig. 1.1 Title page of Stephanus ’ De dissectione partium corporis humani (1545) (Courtesy History & Special Collections for the Sciences, Louise M. Darling Biomedical Library, University of California, Los…
Genetics of Chiari Malformation and Syringomyelia
Proposed inheritance Number of families Affected members Reference study Autosomal dominant with reduced penetrance 21 families Parent–child, siblings, avuncular pairsa, cousins Milhorat et al. (1999) 23 families Parent–child, siblings, avuncular…
Elements of Functional Neuroanatomy: The Major Neurotransmitter Systems
, Damien Gervasoni1 and Catherine Vogt2 (1) Lyon Neuroscience Research Centre CNRS UMR 5292–INSERM U 1028, Université Claude Bernard Lyon 1, Lyon, France (2) Université Claude Bernard Lyon 1, Lyon, France …
Stereotaxic Approach of a Target Structure
, Damien Gervasoni1 and Catherine Vogt2 (1) Lyon Neuroscience Research Centre CNRS UMR 5292–INSERM U 1028, Université Claude Bernard Lyon 1, Lyon, France (2) Université Claude Bernard Lyon 1, Lyon, France …
Preparation of the Stereotaxic Surgical Procedure
, Damien Gervasoni1 and Catherine Vogt2 (1) Lyon Neuroscience Research Centre CNRS UMR 5292–INSERM U 1028, Université Claude Bernard Lyon 1, Lyon, France (2) Université Claude Bernard Lyon 1, Lyon, France …
Realization of the Stereotaxic Surgery
, Damien Gervasoni1 and Catherine Vogt2 (1) Lyon Neuroscience Research Centre CNRS UMR 5292–INSERM U 1028, Université Claude Bernard Lyon 1, Lyon, France (2) Université Claude Bernard Lyon 1, Lyon, France …
