13 Treatment of Degenerative Disc Disease/Disc Regeneration: Stem Cells, Chondrocytes or Other Cells, and Tissue Engineering Steven Presciutti and Howard An Abstract Intervertebral disc (IVD) degeneration remains a significant treatment challenge,…
7 Disc Regeneration: In Vitro Approaches and Experimental Results John T. Martin, Harvey E. Smith, Lachlan J. Smith, and Robert L. Mauck Abstract There has been substantial progress toward disc regeneration…
14 Nucleus Replacement and Repair: Autologous Disc Chondrocyte Transplantation Christian Hohaus, Timothy Ganey, and Hans Jörg Meisel Abstract Intervertebral disc (IVD) degeneration is in 40% of younger individuals and in more…
Fig. 2.1 Degenerative disc disease is a complicated process with many factors interacting to lead to the disc pathology that presents in the clinic. This figure demonstrates many of those…
16 Summary of Clinical Trials with Biological Treatment Approaches for Spinal Disease Gernot Lang, Ibrahim Hussain, Micaella Zubkov, Yu Moriguchi, Brenton Pennicooke, Rodrigo Navarro-Ramirez, and Roger Härtl Abstract Biological-based treatment approaches…
8 Intervertebral Disc Whole Organ Cultures Marianna Peroglio, Zhen Li, Lorin Michael Benneker, Mauro Alini, and Sibylle Grad Abstract Whole intervertebral disc (IVD) organ cultures bridge the gap between in vitro…
4 Biomechanics of the Healthy and Diseased Spine Hans-Joachim Wilke and Fabio Galbusera Abstract The intervertebral disc (IVD) is a pad of soft tissue that uniformly distributes the stresses due to…
