Biological Treatment Approaches: Basic Ideas and Principles
9 Biological Treatment Approaches: Basic Ideas and Principles Victor Y. Leung and Kenneth M.C. Cheung Abstract Clinical studies indicate an association of intervertebral disc (IVD) degeneration severity with low back pain,…
Trial Designs to Establish Efficacy and Safety in Multimodal Therapies
5Trial Designs to Establish Efficacy and Safety in Multimodal Therapies Highlights Developing and evaluating multimodal strategies to treat complex diseases will require innovative strategies and the involvement of multiple stakeholders…
Role of Research Funders in Multimodal Therapy Development
7Role of Research Funders in Multimodal Therapy Development Highlights Government and charitable funding agencies can play an important role in filling the gaps that may exist in the development of…
Multimodal Therapy: Overview of Principles, Barriers, and Opportunities
2Multimodal Therapy: Overview of Principles, Barriers, and Opportunities Multimodal therapies are intended to optimize treatment of brain disorders by delivering different types of therapy together. The multiple modes used may…
Regulatory and Reimbursement Considerations
4Regulatory and Reimbursement Considerations Highlights Multimodal therapies represent an emerging area to the FDA; sponsors are encouraged to consult with the agency at early stages of development (Peña). The FDA…
Developing Multimodal Therapies: Practical Considerations Relating to Industry
6Developing Multimodal Therapies: Practical Considerations Relating to Industry Highlights Even when a multimodal or other innovative therapy provides increased value, barriers exist with regard to adoption, use, and reimbursement (Nye)….
Introduction
1Introduction1 Multimodal therapy approaches that combine interventions aimed at different aspects of disease are emerging as potential—and perhaps essential—ways to enhance clinical outcomes for patients with psychiatric and neurological disorders….
