42-Year-Old Man with Biphasic Synovial Sarcoma
Figure 16-1 A lesion of the tibial nerve before its bifurcation into medial and lateral plantar divisions is seen on the noncontrast T1-weighted MRI image (arrow, right panel). The axial…
Multiple Mononeuropathy and B-Cell Lymphoma: Hepatitis C Polyneuropathy
Figure 58-1 Sural nerve biopsy demonstrates severe axonal loss with perivascular lymphocytic infiltration (Epon) in the epineurium (left) and CD79a positivity of lymphocytes (right). CONCLUSIONS The exact incidence of extrahepatic…
Chronic Lymphocytic Leukemia Causing Multiple Mononeuropathies
Figure 59-1 A, Transverse paraffin section stained with Luxol fast blue/periodic acid–Schiff demonstrating injury neuroma. Transverse paraffin sections stained with hematoxylin and eosin (B) demonstrating perivascular epineurial inflammatory cells with…
Focal Mononeuropathy Onset of Amyotrophic Lateral Sclerosis
A key pathologic feature characteristic of ALS neurons is the presence of intracytoplasmic deposits of ubiquinated immunoreactive inclusions, recently shown to be the protein TDP-43, a nuclear factor about which…
Predominant Peripheral Nerve Involvement in AL Amyloidosis
Figure 55-1 Serial longitudinal paraffin sections show congophilic deposits surrounding endoneurial microvessels (Congo red stain, upper left) and apple green birefringence under polarized light (upper right). The section in the…
Late-Onset Transthyretin Val30Met Familial Amyloid Polyneuropathy Unrelated to Endemic Foci
Sensory deficit Sensory deficit Sensory dissociation Common Rare Autonomic dysfunction in early stages Severe with ADL disturbance Mild without ADL disturbance Cardiac involvement Atrioventricular conduction block Cardiomegaly Anticipation of age…
Reversible Upper and Lower Motor Neuron Disease Persisting Long After Infliximab Therapy
Figure 54-1 The structure of infliximab. (Adapted from Knight DM, Trinh H, Le J, Siegel S, Shealy D, McDonough M, Scallon B, et al. Construction and initial characterization of a…
Severe Sensorimotor Radiculoplexus Neuropathy Following Bariatric Surgery
Figure 52-1 Sural nerve biopsy from a patient with peripheral neuropathy after bariatric surgery demonstrating very active axonal degeneration. Teased fiber preparations (upper left) show almost all fibers are undergoing…
Sarcoid Polyradiculoneuropathy Unresponsive to Corticosteroids
Figure 50-1 Selected microscopic fields from sural biopsy from the patient presented. The upper frame is a paraffin section stained with hematoxylin and eosin that demonstrates a giant cell (arrow)…
Multifocal Motor Neuropathy: Recovery After 107 Six-Weekly Infusions of High Dose Immunoglobulin
Figure 44-1 Cross-section of right sural nerve biopsied at ankle level. Nerve conduction studies of this nerve performed 1 week before biopsy were within normal limits. This methylene blue–stained semithin…
