Abstract Neonatal encephalopathy occurs in 2 to 5/1000 live births and is principally related to hypoxic-ischemic injury to the newborn brain in the immediate peripartum period. In the last decade,…
Abstract The major unifying clinical manifestations of disorders of the neonatal motor system are hypotonia and weakness, which do not necessarily occur with similar severity. In this chapter, all disorders,…
Abstract Degenerative disorders of the newborn are relatively rare. Nonetheless, they are important to recognize because a few are treatable when diagnosed early. Dividing these disorders into those that primarily…
Abstract Drugs can exert major effects on the developing central nervous system (CNS). In the broadest sense, drugs may disturb specific developmental events in the brain and, in turn, produce…
Abstract Neuromuscular disorders may cause dramatic disability in the neonatal period. The dominant features of these disorders are muscle weakness and hypotonia. In this context, we consider as neuromuscular disorders…
Abstract Seizures represent the most distinctive and frequent manifestations of neurological disease in the neonatal period. Compared with seizures in older patients, neonatal seizures have different clinical appearances, electrographic characteristics,…
Abstract Organizational events occur in a peak time period from approximately the fifth month of gestation to several years after birth. The major developmental features include (1) establishment and differentiation…
Abstract A variety of specialized studies are available for evaluating the nervous system of the newborn. In this chapter, we review several commonly used tests: cerebrospinal fluid examination, evoked responses…
Abstract There are numerous disorders of amino acid (AA) metabolism; although individually rare, they collectively are extremely important. First, they may result in devastating disturbances of neurological development, and, second,…
