Autophagy and Novel Therapeutic Strategies in Neuroblastoma
Abstract In the cell, autophagy is the major regulatory catabolic mechanism responsible for the maintenance of cellular homeostasis. It is active at a basal level in all cell types, and…
NEUROLOGY
Immunotherapy for Neuroblastoma
Abstract Current therapeutic approaches for high-risk neuroblastoma include dose-intensive chemotherapy, surgical and radiotherapeutic interventions that are associated with long- and short-term toxicities. Immunotherapy utilizes mechanisms of action that are not…
Current Pharmacotherapy for Neuroblastoma
Abstract Neuroblastoma is, at once, a common and a frequently deadly cancer seen almost exclusively in children. The prognosis for patients with neuroblastoma is best in those whose tumor burden…
Current Challenges in the Management of Neuroblastoma: Noncoding RNA Influences
Abstract Neuroblastoma diagnostic criteria and therapeutic options have been identified and implemented within the oncology clinical setting as best possible and in a timely manner following the ever-changing advances in…
Role of Stemness Factors in Neuroblastoma: Neuroblastoma Stem Cells, Tumor Microenvironment, and Chemoresistance
Abstract The cancer stem cell paradigm is the idea that subpopulations of cancer cells exist within a tumor that are capable of self-renewal, multipotency, proliferation, and tumor maintenance. This subpopulation…
Energy Metabolism and Metabolic Targeting of Neuroblastoma
Abstract Energy metabolism refers to all the reactions involved in generating adenosine triphosphate (ATP) from nutrients, including both aerobic respiration (oxygen present), anaerobic respiration (fermentation) as well as fatty acid…
Neuroblastoma Pathology and Classification for Precision Prognosis and Therapy Stratification
Abstract Tumors in neuroblastoma group offer one of the best models for investigating the biologically significant relationship between their genetic/molecular properties and morphologic manifestations. Over the past decades, histopathological analysis…
Neuroblastoma: Molecular Mechanisms and Therapeutic Interventions
Abstract Improved understanding of the molecular changes involved in oncogenesis has generated considerable interest in developing therapeutic agents that target dysregulated pathways and malfunctioning or overexpressed molecules in cancer. This…
GD2-Targeted Immunotherapy of Neuroblastoma
Abstract Disialoganglioside GD2 is highly expressed on neuroectodermal tumors and sarcomas, but only weakly expressed on limited normal tissues. It has been identified as a marker for a subset of…
Role of Genetic and Epigenetic Alterations in Pathogenesis of Neuroblastoma
Abstract Neuroblastoma is a solid embryonal tumor of the sympathetic nervous system. The clinical course of patients with neuroblastoma is highly heterogeneous, from localized tumors and spontaneous regression to early…
