Fig. 13.1 ACTH-producing PanNET. The tumor cells grow in solid sheets (H&E, ×200) Fig. 13.2 ACTH-producing PanNET with a trabecular pattern of growth and moderate stromal fibrosis (H&E, ×200) Fig….

Fig. 5.1 A 35-year-old female with weight loss and jaundice. Initial investigations revealed a 7 cm mass in the pancreatic head. An endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) with rapid…

Fig. 18.1 Mixed adenoneuroendocrine carcinoma (MANEC) of the pancreas. (a) In the left half of the image, the pancreatic ductal adenocarcinoma component is composed of well-differentiated glandular structures within desmoplastic…

Fig. 11.1 Histologic features of VIPoma: (a) trabecular pattern, (b) diffuse pattern interrupted by cystic spaces containing pale serum-like material, (c) oncocytic area of a VIPoma with some lipid-rich foam…

Fig. 17.1 Small cell carcinomas are characterized by loosely arranged sheets of small cells with a high N:C ratio, hyperchromatic and finely granular chromatin, inconspicuous nucleoli, and nuclear molding. High…

Fig. 14.1 Serotonin-producing PanNETs show different architectural features including trabecular (a) or acinar (b) patterns of growths, and some cases can present marked stromal fibrosis (c). Although serotonin-producing PanNETs are…

Fig. 9.1 Cutaneous manifestations of necrolytic migratory erythema. Glossitis (a) may be associated with the cutaneous lesions (b). The lesions are erythematous and polycyclic. The skin biopsy (c) shows a…

Fig. 8.1 Large pancreatic insulinoma with amyloid stroma (hematoxylin eosin saffron, original magnification ×120) Fig. 8.2 Higher magnification showing well-differentiated neuroendocrine cells, without mitotic figures (hematoxylin eosin saffron, original magnification…

Year Research Investigators 1924 Isolation of PTH Collip 1944 Isolation of GH Li et al. 1982 Isolation of GHRH Guillemin et al./Rivier et al.a First report of functioning GHRH-producing PanNET…

Fig. 7.1 Immunohistochemical localization of islet cell hormones in normal islets. (a) Insulin localization in approximately 60–70 % of islet cells. (b) Glucagon localization in the periphery of the islets…