Neupsy Key

(1) Asheville, NC, USA   In thinking about how a protein might look in its three-dimensional fully folded form, Hsien Wu had envisioned it as forming a crystalline solid composed…

(1) Asheville, NC, USA   The reversible folding and unfolding of proteins uncovered by Anfinsen and Pauling was a landmark event. It established the primacy of the amino acid sequence…

(1) Asheville, NC, USA   By the early 1900s proteins had been studied for more than a hundred years. Chemists had begun to extract proteins such as albumin and wheat…

(1) Asheville, NC, USA   The search for a specific biochemical cause of Alzheimer’s disease began in the 1960s and 1970s, and was inspired by the burgeoning success of levodopa…

(1) Asheville, NC, USA   The 1930s, 1940s, and 1950s were a time of change for how proteins were viewed. Results from X-ray crystallography and denaturation experiments guided the way…

(1) Asheville, NC, USA   The year 2017 will mark the 200th anniversary of the 1817 publication of James Parkinson’s monograph “An Essay on the Shaking Palsy.” In his monograph,…

(1) Asheville, NC, USA   Protein quality control is carried out continuously throughout the cell—in the cytosol, in the endoplasmic reticulum, in the mitochondria and everywhere else. It is an…

(1) Asheville, NC, USA   Recall from Chap. 1 that it took a visit to Papua New Guinea in the mid-1950s. At that time a rare but fatal disease, kuru,…

(1) Asheville, NC, USA   The year 2001 witnessed the publication of the human genome sequence by two consortia, one headed by Eric Lander (in Nature) and the other led…

(1) Asheville, NC, USA   Frontotemporal lobar degeneration (FTLD) is the most common cause of dementia in individuals under the age of 60 years, and overall, follows Alzheimer’s disease and…