Liver-Directed Therapies in Neuroendocrine Tumors
Fig. 26.1 A 45-year-old man with small bowel neuroendocrine tumor, with left hepatectomy for liver metastasis. (a) Axial CT scan (arterial phase) shows new metastatic liver lesion in the remnant…
Epidemiology of Neuroendocrine Tumors
Location Within NETs (%) Within GEP-NETs Incidence SEER (/100,000) Incidence (% of primary site) 5-year OS (%) GEP-NETs 67 5.25 <2 75–82 Gastric 9–20 0.3 1 45–64 Small intestine 39–42…
Targeted Therapies
Gene Pancreatic NET (%) n = 48 Intestinal NET (%) n = 68 MEN-1 44 2 DAXX 25 0 ATRX 18 0 TSC2 9 0 PTEN 7 0 PIK3CA 1 2 VHL 0 2…
Glucagonoma
, Cenk Sokmensuer2 and Ece Esin3 (1) Department of Medical Oncology, Cancer Institute, Hacettepe University, Sihhiye, Ankara, Turkey (2) Department of Pathology, School of Medicine, Hacettepe University, Ankara, Turkey (3) Department of…
Peptide Receptor Radionuclide Therapy
Radiopharmaceutical Administered activity Number of cycles Time interval between cycles (weeks) 90Y-DOTATATE/90Y-DOTATOC 3.7 GBq (100 mCi)/m2 2 10–12 90Y-DOTATATE/90Y-DOTATOC (another protocol) 2.78–4.44 GBq (75–120 mCi) 2–4 10–12 177Lu-DOTATATE/177Lu DOTATOC 5.55–7.4…
The Multiple Endocrine Neoplasia Syndromes
Organ involved Specific tumor (prevalence by 40 years) Clinical presentation MEN1 Parathyroid disease (95 %) Diffuse hyperplasia Symptoms related to hypercalcemia or hypercalciuria Adenoma, multiple NETs PNETs (30–80 %)…
Societies and Guidelines for Neuroendocrine Tumors
© Springer-Verlag Berlin Heidelberg 2015Suayib Yalcin and Kjell Öberg (eds.)Neuroendocrine Tumours10.1007/978-3-662-45215-8_33 33. Societies and Guidelines for Neuroendocrine Tumors Kjell Öberg1 (1) Endocrine Oncology, Uppsala University Hospital, Uppsala, Sweden Kjell Öberg Email: kjell.oberg@medsci.uu.se 33.1 Historical Background…
Chemotherapy
11. Therasse P, Arback SG, Eisenhauer EA et al (2000) New guidelines to evaluate the response to treatment in solid tumors: European Organization for Research and Treatment of Cancer (EORTC),…
Somatostatin Analogs and Interferon in the Treatment of Neuroendocrine Tumors
© Springer-Verlag Berlin Heidelberg 2015Suayib Yalcin and Kjell Öberg (eds.)Neuroendocrine Tumours10.1007/978-3-662-45215-8_30 30. Somatostatin Analogs and Interferon in the Treatment of Neuroendocrine Tumors Jonathan Strosberg1 (1) Neuroendocrine Tumor Program, H. Lee Moffitt Cancer Center and Research Institute,…
Management of Hormonal Symptoms
Tumor type Oversecretion of main substances Clinical syndromes All NENs CgA Carcinoid Serotonin Carcinoid syndrome Insulinoma Insulin, C peptide or proinsulin Hypoglycemia and neuroglycopenia Gastrinoma Gastrin Zollinger-Ellison syndrome (ZES) Glucagonoma…
