Perispinal Etanercept for Traumatic Brain Injury

Jun 26, 2019 by in NEUROLOGY Comments Off on Perispinal Etanercept for Traumatic Brain Injury

Abstract Brain dysfunction after traumatic brain injury (TBI) may involve a persistent neuroinflammatory response that can last for years following acute brain insult. This neuroinflammatory response may include microglial activation…

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Atorvastatin in the Treatment of Traumatic Brain Injury

Jun 26, 2019 by in NEUROLOGY Comments Off on Atorvastatin in the Treatment of Traumatic Brain Injury

Abstract Statins have been recently investigated as a novel neurotherapeutic medication to prevent secondary injury in patients with traumatic brain injury. Through a number of mechanisms including antiapoptotic effects, increased…

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Erythropoietin and Its Derivatives : Mechanisms of Neuroprotection and Challenges in Clinical Translation

Jun 26, 2019 by in NEUROLOGY Comments Off on Erythropoietin and Its Derivatives : Mechanisms of Neuroprotection and Challenges in Clinical Translation

Abstract Erythropoietin (EPO) was first identified as a regulator of erythropoiesis. Additional studies have demonstrated a myriad of pleotropic effects (eg, an ability to decrease inflammation, oxidative stress, and apoptosis)….

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Why Did the Phase III Clinical Trials for Progesterone in TBI Fail? An Analysis of Three Potentially Critical Factors

Jun 26, 2019 by in NEUROLOGY Comments Off on Why Did the Phase III Clinical Trials for Progesterone in TBI Fail? An Analysis of Three Potentially Critical Factors

Abstract Despite hundreds of positive preclinical studies and two successful Phase II clinical trials, two large Phase III trials of progesterone treatment for traumatic brain injury were recently ended with…

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