Memantine : A Safe and Tolerable NMDA Antagonist with Potential Benefits in Traumatic Brain Injury

Jun 26, 2019 by in NEUROLOGY Comments Off on Memantine : A Safe and Tolerable NMDA Antagonist with Potential Benefits in Traumatic Brain Injury

Abstract The potent neuroprotective properties of N -methyl-d-aspartate (NMDA) antagonists have been well established in experimental models of neurological insults in which excitotoxicity is contributory. However, early clinical trials using…

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Docosahexaenoic Acid and Omega 3 Fatty Acids

Jun 26, 2019 by in NEUROLOGY Comments Off on Docosahexaenoic Acid and Omega 3 Fatty Acids

Abstract Administration of omega 3 polyunsaturated fatty acids (n-3 PUFAs) is a biologically plausible, yet clinically untested, candidate therapeutic strategy to prevent or blunt neurologic disability after traumatic brain injury…

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Treatment of Mood Disorders Following Traumatic Brain Injury

Jun 26, 2019 by in NEUROLOGY Comments Off on Treatment of Mood Disorders Following Traumatic Brain Injury

Abstract Mood disorders secondary to traumatic brain injury (TBI) are a relatively common phenomenon. Having a strong understanding of the risk factors, diagnostic procedures, and currently available treatments strengthens clinicians’…

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Ceftriaxone Treatment of TBI

Jun 26, 2019 by in NEUROLOGY Comments Off on Ceftriaxone Treatment of TBI

Abstract Traumatic brain injury (TBI) leads to excess glutamate release from dead and dying neurons, and consequently to secondary neuronal damage weeks and months after initial injury. The GLT-1 (EAAT2…

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5-Lipoxygenase-Activating Protein Inhibitors: Promising Drugs for Treating Acute and Chronic Neuroinflammation Following Brain Injury

Jun 26, 2019 by in NEUROLOGY Comments Off on 5-Lipoxygenase-Activating Protein Inhibitors: Promising Drugs for Treating Acute and Chronic Neuroinflammation Following Brain Injury

Abstract As part of the innate immune response, leukotrienes initiate the first line of defense against tissue damage. They also play key pathological roles in chronic inflammatory diseases like asthma….

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