Treating the violent patient with psychosis or impulsivity utilizing antipsychotic polypharmacy and high-dose monotherapy

Mar 19, 2017 by in PSYCHIATRY Comments Off on Treating the violent patient with psychosis or impulsivity utilizing antipsychotic polypharmacy and high-dose monotherapy

Figure 21.1 Antipsychotic treatment algorithm. Following several unsuccessful atypical antipsychotic monotherapy trials, a trial with a conventional antipsychotic or with clozapine is recommended. High-dose monotherapy may also be considered for…

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Deconstructing violence as a medical syndrome: mapping psychotic, impulsive, and predatory subtypes to malfunctioning brain circuits

Mar 19, 2017 by in PSYCHIATRY Comments Off on Deconstructing violence as a medical syndrome: mapping psychotic, impulsive, and predatory subtypes to malfunctioning brain circuits

Figure 9.1 Heterogeneity of aggression. Identifying the type of aggression a patient is displaying may help guide the selection of appropriate treatments that target the underlying dysfunctional circuits. However, violence…

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Psychosocial approaches to violence and aggression: contextually anchored and trauma-informed interventions

Mar 19, 2017 by in PSYCHIATRY Comments Off on Psychosocial approaches to violence and aggression: contextually anchored and trauma-informed interventions

Figure 28.1 SAMHSA components and principles of recovery for individuals and organizations. Trauma-Informed Perspective There is growing recognition that trauma is widespread, and that the experience of trauma has far-reaching…

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A rational approach to employing high plasma levels of antipsychotics for violence associated with schizophrenia: case vignettes

Mar 19, 2017 by in PSYCHIATRY Comments Off on A rational approach to employing high plasma levels of antipsychotics for violence associated with schizophrenia: case vignettes

Figure 22.1 Relationship between plasma fluphenazine levels and estimated probability of improvement (gray line) and disabling side effects (black line) [20]. Figure 22.2 The relationship between plasma haloperidol and the…

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Effectiveness of antipsychotic drugs against hostility in patients with schizophrenia in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study

Mar 19, 2017 by in PSYCHIATRY Comments Off on Effectiveness of antipsychotic drugs against hostility in patients with schizophrenia in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study

Figure 17.1 Flowchart of patient disposition. The exclusion of data for all 33 patients from one site was caused by concern about the integrity of data from that site. Patients…

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Serotonin and impulsive aggression

Mar 19, 2017 by in PSYCHIATRY Comments Off on Serotonin and impulsive aggression

Figure 15.1a Amygdala BOLD responses to social threat (angry faces) before and after 12 weeks of treatment with placebo (n = 10) vs. fluoxetine (n = 3) or divalproex (n…

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The neurobiology of violence

Mar 19, 2017 by in PSYCHIATRY Comments Off on The neurobiology of violence

Figure 13.1 Amygdala: functional subdivisions and basic organization of flow of information. The amygdala is not a unitary structure, and consideration of its anatomical subdivisions and circuitry is essential. (A)…

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Clozapine: an effective treatment for seriously violent and psychopathic men with antisocial personality disorder in a UK high-security hospital

Mar 19, 2017 by in PSYCHIATRY Comments Off on Clozapine: an effective treatment for seriously violent and psychopathic men with antisocial personality disorder in a UK high-security hospital

No history of self-harm.Index offense: extremely violent murder.OlanzapineD25–29Antisocial-paranoid personality disorder19/24286Numerous assaults, violence toward animals, strangulation, and stabbing.Citalopram, fluoxetine, quetiapine, sertraline, mianserinE50–54Antisocial personality disorder with borderline traits19/24*1848Multiple sexual assaults, violent assaults,…

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