Abstract As part of the innate immune response, leukotrienes initiate the first line of defense against tissue damage. They also play key pathological roles in chronic inflammatory diseases like asthma….
Abstract Traumatic brain injury (TBI) is a leading cause of death and disability in the United States, and, to date, no pharmacological agents are known to improve neurological outcome following…
Abstract In the complex pathophysiology of traumatic brain injury (TBI), nitric oxide (NO) is one of the key molecules with both neuroprotective and neurotoxic effects. Increased NO production have been…
Abstract Paroxysmal sympathetic hyperactivity (PSH) is a dysautonomic syndrome characterized by episodic increases in sympathetic and motor activity. PSH occurs after acquired brain injury of diverse etiology [most often traumatic…
Abstract Brain dysfunction after traumatic brain injury (TBI) may involve a persistent neuroinflammatory response that can last for years following acute brain insult. This neuroinflammatory response may include microglial activation…
Abstract Sulfonylurea receptor 1 (SUR1) is a known component of ATP-sensitive potassium channels in the pancreas but more recently has been identified in association with a nonselective cation channel, transient…
Abstract Statins have been recently investigated as a novel neurotherapeutic medication to prevent secondary injury in patients with traumatic brain injury. Through a number of mechanisms including antiapoptotic effects, increased…
Abstract Erythropoietin (EPO) was first identified as a regulator of erythropoiesis. Additional studies have demonstrated a myriad of pleotropic effects (eg, an ability to decrease inflammation, oxidative stress, and apoptosis)….
Abstract Pressurized tank therapy has existed for hundreds of years, gaining success around the turn of the 20th century. Today, hyperbaric oxygen therapy, or HBOT, is used primarily for decompression…
Abstract The utility of induced hypothermia to mitigate injury to the brain has been long debated in medicine, and it may be the most studied neuroprotectant strategy in traumatic brain…
