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Introduction At the turn of the twentieth century, Dr. Alois Alzheimer described a form of progressive presenile dementia in a female patient named Auguste Deter, who developed memory loss and…
Chapter 1: Introduction Elizabeth Heada,*; Mark Mapstoneb; Ira T. Lottb,c a Department of Pathology & Laboratory Medicine, University of California, Irvine, CA, United Statesb Department of Neurology, University of California, Irvine,…
Genetics of oxidative stress in Down syndrome Growing studies support the hypothesis that oxidative stress (OS) contributes to neurodevelopmental defects, neuronal dysfunction, as well as the accelerated aging phenotype of…
Introduction Individuals with Down syndrome (DS) are at extremely high risk for Alzheimer’s disease (AD), with the vast majority of adults with DS developing AD neuropathology by 40 years of…
Introduction The link between Down syndrome (DS), aging, and Alzheimer’s disease (AD) is well established (see Chapter 1). In people with DS, dementia prevalence increases with age. In those who…
Introduction In the general population there are dramatic individual differences in the severity of cerebrovascular disease with increasing age that promote cognitive decline and clinical symptoms of Alzheimer’s disease (AD)…
