Fig. 17.1 Ipilimumab-related hypophysitis. MRI of the brain in a 77-year-old woman with metastatic melanoma. After the fourth cycle of ipilimumab, she developed profound weakness, fatigue, and confusion, with significant endocrine…
l-Asparaginase Chlorambucil Interferon-a Bevacuzimab Cyclosporin A Lomustine Carmustine Etoposide Methotrexate Cisplatin 5-Fluorouracil Procarbazine Busulphan Ifosfamide Vincristine Table 9.2 Semiology and aetiology of new-onset seizures in cancer Semiology Aetiological condition Isolated generalized…
Clinical history suggesting a brain tumor headache Cancer patient with a new headache or a change in headache pattern Unrelenting crescendo headache Headache resistant to all medical interventions Pain location…
Number of patients Percentage of consults Chief complaint Back pain 385 18 Headache 192 9 Other pain 160 7 Altered mental status 521 24 Weakness 395 18 Sensory deficit…
(1) Department of Neurosurgery, St Elisabeth-Tweesteden Hospital, Tilburg, The Netherlands It is now well known that the brain is electrically excitable. Physicians frequently make use of electromagnetic properties to…
(1) Department of Neurosurgery, St Elisabeth-Tweesteden Hospital, Tilburg, The Netherlands After World War II, the centre of gravity in aphasiology research shifted from Europe to North America [1]. In…
(1) Department of Neurosurgery, St Elisabeth-Tweesteden Hospital, Tilburg, The Netherlands Early anatomists failed to see order amidst the apparent chaos of the brain’s convolutions. It was only in the…
(1) Department of Neurosurgery, St Elisabeth-Tweesteden Hospital, Tilburg, The Netherlands Functional neuroimaging techniques, first positron emission tomography (PET) and later functional MRI (fMRI), have revolutionized cognitive neuroscience. These tools…
(1) Department of Neurosurgery, St Elisabeth-Tweesteden Hospital, Tilburg, The Netherlands In the late nineteenth century, the theory of localization was strongly supported by experimental evidence from both electrocortical stimulation…
(1) Department of Neurosurgery, St Elisabeth-Tweesteden Hospital, Tilburg, The Netherlands Roughly a decade after Broca published his findings on the left frontal speech area, in 1874 Carl Wernicke (1848–1905)…
