Neupsy Key

science revisited mechanisms linked to the development of diabetic polyneuropathy Excessive flux of polyols (sugar alcohols) such as sorbitol, which alter Schwann cell and neuronal function Disease of small blood…

tips and tricks Patients unable to walk 5 m (Hughes scale score ≥3) require intensive monitoring. Patients with autonomic dysregulation or who fail the “20/30/40” test should be monitored in…

The toxin is initially synthesized as a single-chain polypeptide and is subsequently cleaved to yield a heavy chain linked by a disulfide bond to a light chain. After endocytosis, the…

science revisited The underlying pathomechanism of sporadic ALS remains elusive. A complex interplay of genetic and environmental factors is likely involved in the etiology of motor neuron degeneration. Some risk…

Disease severity is associated with age at onset, with the most severe forms of the disease presenting during infancy as first described in the late nineteenth century by Werdnig and…

tips and tricks neuropathies secondary to the direct effects of malignancies The most common cause of neuropathy in patients with cancers is chemotherapy-induced neuropathy An infiltrative brachial plexopathy is more…

Dysphagia usually follows ptosis by a few years, although it may precede ptosis in some patients. It tends to be more severe for solids than for liquids and can be…

tips and tricks Keep dystrophin deficiency in the differential diagnosis for both muscle and cognitive complaints. Think of a dystrophinopathy in any male or female at any age presenting with…

tips and tricks clinical features that raise suspicion for fshd Facial weakness and shoulder weakness with little or no lower extremity weakness Typical appearance of the shoulder: forward sloping shoulders,…

caution! muscle biopsy Muscle biopsy evidence of reversible statin myopathy can occur without any overt clinical symptoms and with normal creatine kinase (CK) levels. Therefore, the decision to proceed with…