Fig. 19.1 Multihormonal microadenoma in the MEN1 pancreas immunostained for (a) glucagon and (b) pancreatic polypeptide In MEN1 patients, all somatic cells harbor a heterozygous germline mutation of the MEN1…
WHO class Definition Grade Mitosis Ki67% I NET G1 <2 ≤2 II NET G2 2–20 3–20 III NEC G3 >20 >20 IV MANEC nd nd nd V Hyperplasia/dysplasia na na…
Fig. 2.1 Functioning PanNETs US. Small insulinoma of pancreatic body. Axial scan: hypoechoic mass (calipers) with smooth margins and about 1 cm in diameter, located at the anterior border of…
Fig. 13.1 ACTH-producing PanNET. The tumor cells grow in solid sheets (H&E, ×200) Fig. 13.2 ACTH-producing PanNET with a trabecular pattern of growth and moderate stromal fibrosis (H&E, ×200) Fig….
Fig. 5.1 A 35-year-old female with weight loss and jaundice. Initial investigations revealed a 7 cm mass in the pancreatic head. An endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) with rapid…
Fig. 18.1 Mixed adenoneuroendocrine carcinoma (MANEC) of the pancreas. (a) In the left half of the image, the pancreatic ductal adenocarcinoma component is composed of well-differentiated glandular structures within desmoplastic…
Fig. 17.1 Small cell carcinomas are characterized by loosely arranged sheets of small cells with a high N:C ratio, hyperchromatic and finely granular chromatin, inconspicuous nucleoli, and nuclear molding. High…
Fig. 14.1 Serotonin-producing PanNETs show different architectural features including trabecular (a) or acinar (b) patterns of growths, and some cases can present marked stromal fibrosis (c). Although serotonin-producing PanNETs are…
Fig. 9.1 Cutaneous manifestations of necrolytic migratory erythema. Glossitis (a) may be associated with the cutaneous lesions (b). The lesions are erythematous and polycyclic. The skin biopsy (c) shows a…
