Neurophysiologic Basis of the Electroencephalogram Erwin-Josef Speckmann Christian E. Elger Ulrich Altrup Field potentials appear and are detectable in the space surrounding cellular elements of the nervous system. They comprise…
The Natural History of Seizures W. Allen Hauser Descriptive epidemiologic studies provide information about the frequency of epilepsy and other convulsive disorders in the population. Individuals identified in these cohorts…
Epidemiologic Aspects of Epilepsy Anne T. Berg Until the 1960s, the prevailing view about epilepsy was captured by the words of Sir William Gowers: “The tendency of the disease is…
Genetics Aspects of Epilepsy and Genetics of Idiopathic Generalized Epilepsy Ajay Gupta Ingrid E. Scheffer Epilepsy, defined by the recurrence of unprovoked seizures, is a complex disorder. Complex inheritance refers…
Mechanisms of Epileptogenesis and Experimental Models of Seizures Imad Najm Gabriel Möddel Damir Janigro The term epileptogenesis refers to abnormal firing of neurons sufficient to produce episodic epileptiform electrophysiologic activity…
Basic Cellular Neurophysiology Stephen W. Jones ION CHANNELS AND INTRINSIC MEMBRANE PROPERTIES Basis of Electrical Activity The activity of ion channels is fundamental to signaling in the nervous system. Synaptic…
Human Nervous System Development and Malformations Harvey B. Sarnat Laura Flores-Sarnat Development of the brain, both normal and abnormal, is the result of genetically determined events that occur sequentially but…
Hippocampal Anatomy and Hippocampal Sclerosis Imad Najm Henri Duvernoy Stephan Schuele HIPPOCAMPAL ANATOMY Because the hippocampal formation is frequently involved in patients with focal epilepsy, a thorough knowledge of this…
Malformations of Cortical Development and Epilepsy William B. Dobyns Ruben Kuzniecky Development of the human brain is a complex process that begins with appearance of the notochord and continues long…
