Ceftriaxone Treatment of TBI
Abstract Traumatic brain injury (TBI) leads to excess glutamate release from dead and dying neurons, and consequently to secondary neuronal damage weeks and months after initial injury. The GLT-1 (EAAT2…
NEUROLOGY
TrkB Receptor Agonist 7,8-Dihydroxyflavone and Its Therapeutic Potential for Traumatic Brain Injury
Abstract Traumatic brain injury (TBI) is a major health problem worldwide. Following the primary injury, there is no cure to rescue the damaged neural tissue. Current treatment options for TBI…
The Use of Estrogen for the Treatment of Traumatic Brain Injury
Abstract It is known that estrogen can mitigate neurological injury. However, to optimize estrogen’s benefits, it must be administered as soon as possible postinjury, preferably within the “golden hour.” We…
5-Lipoxygenase-Activating Protein Inhibitors: Promising Drugs for Treating Acute and Chronic Neuroinflammation Following Brain Injury
Abstract As part of the innate immune response, leukotrienes initiate the first line of defense against tissue damage. They also play key pathological roles in chronic inflammatory diseases like asthma….
Voltage-Gated Calcium Channel Blockers for the Treatment of Traumatic Brain Injury
Abstract Traumatic brain injury (TBI) is a leading cause of death and disability in the United States, and, to date, no pharmacological agents are known to improve neurological outcome following…
Nitric Oxide Synthase Inhibitors in Traumatic Brain Injury
Abstract In the complex pathophysiology of traumatic brain injury (TBI), nitric oxide (NO) is one of the key molecules with both neuroprotective and neurotoxic effects. Increased NO production have been…
Management of Paroxysmal Sympathetic Hyperactivity After Traumatic Brain Injury
Abstract Paroxysmal sympathetic hyperactivity (PSH) is a dysautonomic syndrome characterized by episodic increases in sympathetic and motor activity. PSH occurs after acquired brain injury of diverse etiology [most often traumatic…
Perispinal Etanercept for Traumatic Brain Injury
Abstract Brain dysfunction after traumatic brain injury (TBI) may involve a persistent neuroinflammatory response that can last for years following acute brain insult. This neuroinflammatory response may include microglial activation…
The Application of Glibenclamide in Traumatic Brain Injury
Abstract Sulfonylurea receptor 1 (SUR1) is a known component of ATP-sensitive potassium channels in the pancreas but more recently has been identified in association with a nonselective cation channel, transient…
Atorvastatin in the Treatment of Traumatic Brain Injury
Abstract Statins have been recently investigated as a novel neurotherapeutic medication to prevent secondary injury in patients with traumatic brain injury. Through a number of mechanisms including antiapoptotic effects, increased…
