Neupsy Key

Fig. 8.1 Large pancreatic insulinoma with amyloid stroma (hematoxylin eosin saffron, original magnification ×120) Fig. 8.2 Higher magnification showing well-differentiated neuroendocrine cells, without mitotic figures (hematoxylin eosin saffron, original magnification…

Year Research Investigators 1924 Isolation of PTH Collip 1944 Isolation of GH Li et al. 1982 Isolation of GHRH Guillemin et al./Rivier et al.a First report of functioning GHRH-producing PanNET…

Fig. 7.1 Immunohistochemical localization of islet cell hormones in normal islets. (a) Insulin localization in approximately 60–70 % of islet cells. (b) Glucagon localization in the periphery of the islets…

Fig. 3.1 Comparison between 18F-FDG PET/CT and 68Ga-DOTANOC PET/CT in a patient with a nodule in the pancreatic tail incidentally detected at CT. 18F-FDG PET/CT showed no 18F-FDG uptake in…

Fig. 16.1 Clear cell (lipid-rich) variant of pancreatic neuroendocrine tumor in (a). Oncocytic variant of pancreatic nonfunctioning neuroendocrine tumor in (b) Among prognostically relevant histologic findings, there are vascular invasion…

Fig. 10.1 Functioning somatostatinoma characterized by a trabecular architecture (a) and showing somatostatin (b) and calcitonin (c) immunoreactivity (H original magnification ×400; immunohistochemistry original magnification ×200) Fig. 10.2 Nonfunctioning somatostatin-producing…

Fig. 1.1 (a) Paul Langerhans (1847–1888) in 1873 (© Bildarchiv Preußischer Kulturbesitz, Berlin, 1873, Photographer: Ruf und Dilger [85]) (b) Histological appearance of the islet of Langerhans (hematoxylin-eosin) In 1893,…

Fig. 22.1 Approved and not approved therapies in NENs. IFN interferon, PRRT peptide radioreceptor therapy 22.2 General Approach Therapeutic approach can change according to the functioning/nonfunctioning status of the neoplasm….