Inositol in the Treatment of Psychiatric Disorders Robert H. Belmaker Joseph Levine Inositol is a sugar alcohol and a structural isomer (although not stereo-isomer) of glucose (Fig. 7.1). It differs…
Dehydroepiandrosterone in the Treatment of Neuropsychiatric Conditions Owen M. Wolkowitz Victor I. Reus Nicole Maninger Synthia Mellon Dehydroepiandrosterone (DHEA) has been evaluated in the treatment of neuropsychiatric disorders almost from…
One-Carbon Metabolism and the Treatment of Depression: Roles of S-Adenosyl-L-Methionine and Folate Jonathan E. Alpert George I. Papakostas David Mischoulon The putative psychotropics reviewed in the chapter are formulations of…
Omega-3 Fatty Acids in Mood Disorders: A Review of Neurobiologic and Clinical Actions Andrew L. Stoll INTRODUCTION TO OMEGA-3 FATTY ACIDS Overview and Perspective At the time of the first…
St. John’s Wort: A Critical Evaluation of the Evidence for Antidepressant Effects Andrew A. Nierenberg Hannah G. Lund David Mischoulon Saint John’s wort (SJW), Hypericum perforatum, has a long history…
Evaluating the Data: Limitations of Research and Quality Assurance Issues Regarding Natural Remedies Maurizio Fava David Mischoulon How do we know whether a natural remedy—or any remedy, for that matter—is…
Complementary and Alternative Medicine in Society: An Introduction David Mischoulon Jerrold F. Rosenbaum This chapter was previously published by the author in modified form in the following: Mischoulon D. Nutraceuticals…
Myoglobinuria—the presence in urine of a 17.8-kDa, red pigment, iron-protein compound called myoglobin—results from rhabdomyolysis, which is the acute breakdown or necrosis of skeletal muscle fibers whose contents (among them…
McArdle disease, an autosomal recessive myophosphorylase deficiency leading to glycolytic defects, is the common glycogen storage disease (GSD). Other glycolytic defects—phosphofructokinase, phosphoglycerate mutase, and lactic dehydrogenase deficiencies—produce similar clinical pictures….
Hypothyroid Myopathy. Most patients with myxedema (chronic hypothyroidism) complain of weakness; 25% have objective proximal muscle weakness. Myoedema, an electrically silent mounding of percussed muscle, occurs in one third of…
