8: Neuroimaging
CHAPTER 8Neuroimaging Meneka K. Sidhu, Matthias J. Koepp, and John S. Duncan MR IMAGING Good quality magnetic resonance imaging (MRI) is fundamental to diagnosing the reasons for someone’s epilepsy, and…
15: Epilepsy Surgery
CHAPTER 15Epilepsy Surgery John S. Duncan, Anna Miserocchi, and Andrew McEvoy Surgery may be an effective treatment for drug‐resistant focal epilepsy (DRFE), but the current interval from epilepsy onset to…
7: Neurophysiology
CHAPTER 7Neurophysiology Fahmida A. Chowdhury ELECTROENCEPHALOGRAPHY In 1929, Hans Berger, a German psychiatrist, recorded the first human electroencephalogram (EEG). In the 1940s, Gibbs and colleagues demonstrated 3 Hz spike–wave discharge in…
11: Medical Treatment
CHAPTER 11Medical Treatment Fergus J. Rugg‐Gunn TREATING EPILEPSY Epilepsy treatment has mainly focused on pharmacological options, with almost 30 antiseizure medications (ASM) now available worldwide. For about two‐thirds of people…
14: Status Epilepticus
CHAPTER 14Status Epilepticus Matthew C. Walker STATUS EPILEPTICUS: DEFINITIONS AND CAUSES Most seizures are self‐terminating, usually lasting less than two minutes. On occasion, however, they endure, leading to status epilepticus….
22: Epilepsy and Neurodegeneration
CHAPTER 22Epilepsy and Neurodegeneration Maria Thom and Matthias J. Koepp Epilepsy is more common in older age. Alzheimer’s disease (AD) and epilepsy often co‐exist, and share significant mechanistic overlap. People…
26: Future Perspectives for Epilepsy
CHAPTER 26Future Perspectives for Epilepsy Ley Sander and John S. Duncan EXPECTATIONS Pragmatically, different perspectives shape future expectations, which depend primarily on the roles of stakeholders. People with epilepsy, their…
6: Neuroscience of Epilepsy
CHAPTER 6Neuroscience of Epilepsy Matthew C. Walker and Dimitri M. Kullmann Despite our burgeoning understanding of epilepsy mechanisms, John Hughlings Jackson’s 150‐year‐old definition of epilepsy broadly holds to this day:…
25: Big Data and Artificial Intelligence
CHAPTER 25Big Data and Artificial Intelligence Ali Alim‐Marvasti MACHINE LEARNING AND ARTIFICIAL INTELLIGENCE Artificial intelligence (AI) has been in development for decades. Several factors have contributed to its increasing success:…
24: Functional Dissociative Seizures
CHAPTER 24Functional Dissociative Seizures Mahinda Yogarajah Functional dissociative seizures (FDS) are paroxysmal, time‐limited alterations in motor, sensory, autonomic, and or cognitive signs and symptoms. Superficially, they may resemble epileptic seizures,…
