Figure 21.1. Graphic representation of continuous spike-and-wave during sleep evolution over time. The age of clinical events varies in individual patients but tends to peak at approximately the displayed ages….
Figure 81.1. Intraoperative aspect of SDG/depth electrode implantation in a patient with extratemporal epilepsy and nonlesional MRI. The picture shows a large right-sided temporofrontal craniotomy with placement of SDGs at…
Figure 60.1. Structural formulas of PRM and its main metabolites. CHEMISTRY AND MECHANISM OF ACTION Phenobarbital Chemically, PB is 5-ethyl-5-phenylbarbituric acid (see Fig. 60.1). The molecular weight is 232.23, and…
For those with peri-ictal depression, improved seizure control may be a sufficient treatment. For patients with resistant peri-ictal depression, interictal MDD, persistent depressive disorder, or IDD, antidepressant treatment is indicated….
In a study examining the distribution of 600 focal seizures across the sleep–wake cycle recorded during video–electroencephalogram (EEG) evaluations, 43% were found to arise from sleep, the majority from non–rapid…
Figure 66.1. Zonisamide. MECHANISM OF ACTION There are several pharmacologic effects of zonisamide that may be responsible for its activity as an AED. Results from several studies demonstrate the most…
