Fig. 5.1 Hematoxylin and eosin stain (HE) shows active myopathy with a large collection of lymphocytic infiltrates in perimysium and surrounding a perimysial blood vessel. Alkaline phosphatase stain (ALK) shows…
Fig. 31.1 SMA type 1 . (a) H&E and (b) ATPase at pH 9.4 are images from the rectus abdominis muscle biopsy performed at age of 3 months. (c) H&E of spinal…
Fig. 23.1 Quadriceps muscle biopsy from this patient. (a) H&E stain, arrows point to the macrophages in perimysium and endomysia connective tissue with granular basophilic cytoplasm. (b) Nonspecific esterase stain,…
Fig. 29.1 Representative images from a separate 10-year-old boy with RYR1 mutation. (a) H&E stain shows marked fiber size variation. (b) NADH-TR stain shows well demarcated central cores in type…
Fig. 7.1 Hematoxylin & eosin (HE) statin shows abundant necrotic fibers and myophagocytosis (arrows), increased fiber size variation with many polygonal atrophic fibers, and endomysial and perimysial fibrosis. Alkaline phosphatase…
Fig. 12.1 Quadriceps muscle biopsy from the present patient. HE stain shows increased fiber size variation with a few atrophic and hypertrophic fibers, and numerous internal nuclei. Many fibers contain…
Fig. 17.1 Myofibrillar myopathy. (a) H&E stain. (b) Gomori trichrome stain. (c) NADH-TR stain. (d) ATPase stain at pH 9.4. (e) Desmin immunostain. (f) Granulofilamentous material on electron microscopy Final Diagnosis…
Fig. 42.1 PGP9.5 immunostaining shows normal cutaneous innervation with many intraepidermal nerve fibers (arrows) present at the unaffected right proximal thigh (a), but no intraepidermal nerve fibers are seen at…
Fig. 40.1 PGP9.5 immunostaining of skin biopsy sections shows reduced intraepidermal nerve fiber densities at the left distal leg (a), distal thigh (b) and proximal thigh (c) with no distal-to-proximal…
Fig. 13.1 Glycogen storage myopathy. (a), H&E stain shows many fibers containing subsarcolemmal vacuoles or blebs (arrows). (b), EM shows striking subsarcolemmal glycogen accumulations (arrows) Additional Investigation After the Muscle…
