Brain Death in Adults
12 Brain Death in Adults Rodney D. Bell, Norman Ajiboye, and Yu Kan Au Abstract Since the passage of the Uniform Determination of Death Act of 1981, the concept of…
Transfusion Medicine and Anticoagulation
5 Transfusion Medicine and Anticoagulation Bhuvanesh Govind and Matthew Vibbert Abstract Anemia of critical illness, thromboses, and coagulopathies are common complications in the neurologic intensive care unit (ICU). A judicious…
Brain Tumor Postoperative Management
11 Brain Tumor Postoperative Management Richard F. Schmidt, Nikolaos Mouchtouris, Muaz Qayyum, James J. Evans, and Christopher Farrell Abstract In this chapter, we discuss the critical care management of patients…
Alzheimer’s neuropathology in Down syndrome: From gestation to old age
Introduction At the turn of the twentieth century, Dr. Alois Alzheimer described a form of progressive presenile dementia in a female patient named Auguste Deter, who developed memory loss and…
Introduction
Chapter 1: Introduction Elizabeth Heada,*; Mark Mapstoneb; Ira T. Lottb,c a Department of Pathology & Laboratory Medicine, University of California, Irvine, CA, United Statesb Department of Neurology, University of California, Irvine,…
Oxidative stress and mTOR in Down syndrome brain: Link to Alzheimer’s dysmetabolism, neuropathology, and possible therapies
Genetics of oxidative stress in Down syndrome Growing studies support the hypothesis that oxidative stress (OS) contributes to neurodevelopmental defects, neuronal dysfunction, as well as the accelerated aging phenotype of…
