Figure 16.1 Schematic diagram showing activities of daily living (ADLs) subclassified into basic (Basic ADLs) and instrumental (Instrumental ADLs). The assessment of functional abilities should be included in clinical investigations…
Figure 13.1 Relative frequency of major molecular pathologic subtypes of frontotemporal lobar degeneration (FTLD). FET, fused in sarcoma, Ewing’s sarcoma, TATA-binding protein-associated factor 15 family of proteins; tau, microtubule-associated protein…
Figure 10.1 Regional brain atrophy across three clinical stages of behavioral variant FTD. In the group with very mild dementia (CDR 0.5), atrophy involved areas in the frontal lobe (rostromedial…
Figure 8.1 The complexity of clinicopathologic relationships along the frontotemporal lobar degeneration (FTLD) spectrum. The major clinical syndromes along the FTLD spectrum are shown in the top row of the…
MAPT (tau)GRN (progranulin)TDP-43TauOthersVCPCHMP2BTARDBP (TDP-43)FUSFUS C9ORF72 C9ORF72 is the newest addition to the roster of causative molecules in FTD. In 2011, expansions of a GGGGCC hexanucleotide repeat in C9orf72 were found…
Figure 9.1 The INECO Frontal Screening (IFS) [39]. Classical executive function tests The most frequent classical executive function tests used in patients with bvFTD are: the backward digit span [5],…
Figure 12.1 Pedigree for Case 1. The genetic counselor and neurologist meet with Mr. and Mrs. G. for the disclosure of the genetic testing results, which are positive for a…
Figure 6.1 Calculation of verbal fluency index. The verbal fluency index (Vfi) is calculated using a motor control condition in which after the participant has generated words in the given…
Figure 19.1 The family’s journey to a diagnosis of FTD. Stage I. Something is wrong Whether initial symptoms are word-finding difficulties, a change in energy level, a few lapses in…
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> Chapter 18 Pharmacologic therapy for FTD and related disordersCurrent options and future strategies Richard M. Tsai and Adam L. Boxer Hodges’ Frontotemporal Dementia, Second Edition, ed….
