Imaging of frontotemporal dementia
Figure 10.1 Regional brain atrophy across three clinical stages of behavioral variant FTD. In the group with very mild dementia (CDR 0.5), atrophy involved areas in the frontal lobe (rostromedial…
Overview of clinical assessment of frontotemporal dementia syndromes
Figure 8.1 The complexity of clinicopathologic relationships along the frontotemporal lobar degeneration (FTLD) spectrum. The major clinical syndromes along the FTLD spectrum are shown in the top row of the…
Pathophysiology and animal models of frontotemporal dementia
MAPT (tau)GRN (progranulin)TDP-43TauOthersVCPCHMP2BTARDBP (TDP-43)FUSFUS C9ORF72 C9ORF72 is the newest addition to the roster of causative molecules in FTD. In 2011, expansions of a GGGGCC hexanucleotide repeat in C9orf72 were found…
Neuropsychological assessment of frontotemporal dementia
Figure 9.1 The INECO Frontal Screening (IFS) [39]. Classical executive function tests The most frequent classical executive function tests used in patients with bvFTD are: the backward digit span [5],…
Genetic counseling for FTD
Figure 12.1 Pedigree for Case 1. The genetic counselor and neurologist meet with Mr. and Mrs. G. for the disclosure of the genetic testing results, which are positive for a…
The FTD-ALS spectrum
Figure 6.1 Calculation of verbal fluency index. The verbal fluency index (Vfi) is calculated using a motor control condition in which after the participant has generated words in the given…
The family’s perspective on FTD
Figure 19.1 The family’s journey to a diagnosis of FTD. Stage I. Something is wrong Whether initial symptoms are word-finding difficulties, a change in energy level, a few lapses in…
Pharmacologic therapy for FTD and related disorders
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> Chapter 18 Pharmacologic therapy for FTD and related disordersCurrent options and future strategies Richard M. Tsai and Adam L. Boxer Hodges’ Frontotemporal Dementia, Second Edition, ed….
Practical management of frontotemporal dementia
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> Chapter 17 Practical management of frontotemporal dementia Edward D. Huey and Masood Manoochehri Hodges’ Frontotemporal Dementia, Second Edition, ed. Bradford C. Dickerson. Published by Cambridge University…
Genetics of frontotemporal dementia and related disorders
Figure 14.1 Clinical characteristics associated with the major FTLD genes GRN, C9orf72, and MAPT. Shaded areas represent interquartile distribution of onset age (y-axis) and FTLD subtype (x-axis). Vertical lines represent…
