Immunoglobulin and Immunomodulatory Therapy Flavio Villani Christian G. Bien Giuliano G. Avanzini Introduction The use of immunoglobulin in intractable epilepsy is one of its oldest applications in medicine, starting from…
Investigational Drugs: Brivaracetam, Carisbamate, Eslicarbazepine Fluorofelbamate, Gamaxolone, Isovaleramide, Lacosamide (Harkoseride; SPM927), Losigamine, Retigabine, Safinamide, Seletracetam, Stiripentol, Talampanel, and Valrocemide H. Steve White Emilio Perucca Michael D. Privitera Introduction During the…
Trimethadione, Paraldehyde, Phenacemide, Bromides, Sulthiame, Acetazolamide, and Methsuximide Thomas R. Browne Barbara W. LeDuc Maria D. Kosta-Rokosz Edward B. Bromfield R. Eugene Ramsay John De Toledo Introduction Trimethadione, paraldehyde, phenacemide,…
Zonisamide Masakazu Seino Ilo E. Leppik Introduction After a long hiatus in the development of novel drugs for treating epilepsy, the early 1990s saw several new antiepileptic drugs (AEDs) developed…
Vigabatrin Elinor Ben-Menachem Olivier Dulac Catherine Chiron Introduction Vigabatrin is a novel antiepileptic drug (AED). It differs from most other agents in that it was designed to have a specific…
Topiramate Edward Faught Tracy A. Glauser Introduction Topiramate (TPM) is a broad-spectrum antiepileptic drug with multiple mechanisms of action. It was originally synthesized as part of a search for fructose-related…
Rufinamide Tracy A. Glauser Meir Bialer Introduction Rufinamide is a broad-spectrum antiepileptic drug (AED) with documented ability to block sodium (Na) channels.24,34 Following discovery of antiepileptic activity in animal models,…
