Benzodiazepines
Benzodiazepines Dieter Schmidt Alan J. Wilensky Introduction The benzodiazepines represent a clinically relevant class of compounds that possess a broad range of properties, including anticonvulsant efficacy. In 1965, diazepam was…
Adrenocorticotropic Hormone and Steroids
Adrenocorticotropic Hormone and Steroids Richard A. Hrachovy James D. Frost Jr. Introduction Since the 1950s, adrenocorticotropic hormone (ACTH) and corticosteroids have been used to treat a variety of seizure types…
The Role of European Regulatory Agencies
The Role of European Regulatory Agencies Michel Baulac Eric Abadie Introduction Since 1989, eleven new antiepileptic drugs (AEDs) have been approved in the EU countries for epileptic disorders as indication….
The Role of the Food and Drug Administration
The Role of the Food and Drug Administration Russell Katz The views expressed in this article are those of the author and do not reflect an official position of the…
Pharmacogenetics and Pharmacogenomics
Pharmacogenetics and Pharmacogenomics Nicole Walley Sanjay M. Sisodiya David B. Goldstein Introduction Although pharmacologic treatment successfully controls seizures for a majority of patients with epilepsy, current treatment options are far…
Clinical Trials of Antiepileptic Drugs in Adults and Children
Clinical Trials of Antiepileptic Drugs in Adults and Children Jacqueline A. French Tracy A. Glauser Bernd Schmidt Introduction The modern age of drug testing was ushered in in 1962 by…
Screening of New Compounds and the Role of the Pharmaceutical Industry
Screening of New Compounds and the Role of the Pharmaceutical Industry H. Steve White Roger J. Porter Harvey J. Kupferberg Introduction The search for new antiepileptic drugs (AEDs) requires the…
Molecular Targets for Novel Antiepileptic Drugs
Molecular Targets for Novel Antiepileptic Drugs Brian S. Meldrum Introduction The majority of antiepileptic drugs (AEDs) introduced since 1938 have been identified as anticonvulsants by means of screening tests using…
Basic Principles of Medicinal Chemistry
Basic Principles of Medicinal Chemistry Donald F. Weaver Raman Sankar Introduction Medicinal chemistry is the branch of applied organic chemistry that deals with the design and synthesis of new chemical…
Cellular Effects of Antiepileptic Drugs
Cellular Effects of Antiepileptic Drugs Robert L. MacDonald Michael A. Rogawski Introduction Antiepileptic drugs (AEDs) protect against seizures through interactions with a variety of cellular targets, which include various ion…
