Dose-Related Side Effects Dieter Schmidt Steven C. Schachter Introduction Most antiepileptic drugs (AEDs) block seizure generation by altering membrane excitability, increasing postsynaptic inhibition, or modifying the synchronization of neuronal networks.34…
Efficacy of Antiepileptic Drugs W. Edwin Dodson Martin J. Brodie Introduction Since 1962, when the Kefauver-Harris Drug Amendments were passed, proof of effectiveness and evidence of reasonable safety have been…
Pharmacokinetics Emilio Perucca Introduction Pharmacokinetics is the study of changes in the concentration of drugs or drug metabolites within the body as a function of time. Its clinical importance stems…
Therapeutic Drug Monitoring Svein I. Johannessen Philip N. Patsalos Torbjörn Tomson Emilio Perucca Introduction Therapeutic drug monitoring (TDM) can be defined as “the measurement and the clinical use of drug…
Age-Related Considerations Ann Jacoby Gus A. Baker Introduction The goals of therapy for people with epilepsy were discussed in an earlier chapter. They can be seen as being broadly concerned…
Quantitative Measures of Assessment Gus A. Baker Orrin Devinsky Joanne Taylor Joyce A. Cramer Introduction Quality of life refers to an individual’s overall well-being and daily functioning. Health-related quality of…
Broader Aspects of Treatment David C. Taylor This human ritual of suppliant and provider of balm is deeply rooted; extending back thousands of years. —W. Pickering20 Introduction This chapter is…
Goals of Therapy Lawrence J. Hirsch Timothy A. Pedley Introduction The goal of all medical therapy is to allow patients to live as normally as possible and to maximize quality…
Indications for Treatment John M. Freeman Timothy A. Pedley Introduction Epileptic seizures are among the most common symptoms of disturbed brain function. They result from many causes and can have…
Overview: General Approaches to Treatment David W. Chadwick Roger J. Porter Emilio Perucca John M. Pellock Introduction After making the correct diagnosis of a patient but before writing the prescription…
