Inflammation Annamaria Vezzani Jukka Peltola Damir Janigro Introduction Immune and inflammatory reactions have been described in the central nervous system (CNS) in various neurologic diseases, including epilepsy. In particular, several…
Voltage-Gated Ion Channels: Molecular Biology and Role of Mutations in Epilepsy Dimitri M. Kullmann Stephanie Schorge Introduction Voltage-gated ion channels have long been known to be central to the excitability…
GABAA and GABAB Receptor-Mediated Inhibitory Synaptic Transmission Robert L. MacDonald Istvan Mody Introduction The neurotransmitter γ-aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the central nervous system (CNS)….
Excitatory Synaptic Transmission Karen S. Wilcox Peter J. West Marc A. Dichter Introduction Information processing throughout the central nervous system (CNS) occurs through synaptic transmission between neurons coupled via chemical…
Control of Neuronal Excitability Uwe Heinemann Istvan Mody Yoel Yaari Introduction The behavior of nerve cells is determined by ionic channels. These are transmembrane proteins with a pore that permits…
Overview: The Neurobiology of Epilepsy Marc A. Dichter Introduction The epilepsies are a complex group of disorders whose common feature is a tendency for hyperexcitability to develop in one or…
Genetic Counseling Frances Elmslie Introduction Genetic counseling has become an integral component of care of many conditions that display mendelian inheritance, and increasingly those that show complex inheritance, such as…
Genetics of Epilepsy Syndromes Ortrud K. Steinlein Introduction The term epilepsy describes a heterogeneous group of disorders, with a lifetime cumulative incidence of 3%. There are disorders in which seizures…
Genetic Diseases Associated with Epilepsy Joshua L. Bonkowsky Martha A. Nance W. Allen Hauser V. Elving Anderson Introduction Genetics has become increasingly important for understanding epilepsy. Since the advent of…
EEG Traits Timothy A. Pedley Introduction At the most fundamental level, cortical excitability and electrical organization are genetically specified, and it is probable that each identifiable electroencephalographic (EEG) pattern is…
