Keywords brain metastases, non-small cell lung cancer, epidermal growth factor receptor, urokinase-type plasminogen activator receptor, diphtheria toxin, DTATEGF, bioluminescence, in vivo , in vitro   Outline Introduction 157 Diphtheria Toxin…

Keywords brain metastases, non-small cell lung cancer, EGFR mutation, epidermal growth factor receptor tyrosine kinase inhibitors, gefitinib, erlotinib   Outline Introduction 142 Treatment Options for Brain Metastases 145 Whole Brain…

Keywords brain metastasis, surgical resection, stereotactic radiosurgery, whole brain irradiation, non-small cell lung cancer, linear accelerator   Outline Introduction 131 Technical and Technological Aspects 132 Radiobiological Issues and Clinical Data…

Keywords metastasis, chemokines, signaling pathways, CX3CR1, non-small cell lung cancer, NSCLC, small cell lung cancer, SCLC   Outline Introduction 123 Organotropic Spread of Lung Carcinoma: Role of Chemokine Signaling Pathways…

Keywords brain metastasis, non-small cell lung cancer, epidermal growth factor receptor mutation, treatment, whole brain radiotherapy, epidermal growth factor receptor tyrosine-kinase inhibitors, gefitinib, erlotinib   Outline Introduction 114 Brain Metastasis…

Keywords synovial sarcoma, metastasis, in continuity, hematogenous, treatment   Outline Introduction 93 Brain Synovial Sarcomas 93 Synovial Sarcoma 94 Epidemiology 94 Clinical Features 94 Radiology 95 Pathology 95 Genetics 96…

Keywords brain metasases, whole brain radiation therapy, radiosurgery, side effects   Outline Introduction 81 Whole Brain Radiation Therapy 82 Whole Brain Radiation Therapy Technique 82 Whole Brain Radiation Therapy Tumor…

Keywords brain metastases, chemotherapy, non-small cell lung cancer, breast cancer, melanoma   Outline Introduction 75 Standard of Care for Brain Metastases 76 Current Chemotherapy Options for Brain Metastases 77 Non-Small…

Keywords second malignancy, neuroblastoma, children, survival, treatment, genetic aberrations   Outline Introduction 61 Risk of SMN in Children Treated for Neuroblastoma 62 Incidence of Selected SMNs 63 Leukemias and Lymphomas…

Keywords brain metastases, angiogenesis, blood–brain barrier, radiosensitizing, radiotherapy   Outline Introduction 53 Targeting Angiogenesis for Brain Metastases 54 Sensitizing Brain Metastases to Radiation 55 Crossing the Blood–Brain Barrier 56 Conclusion…