Year Discovery/landmark/reference Pregenomic era 1871 Discovery of nucleic acids 1889 Hugo de Vries postulated “pangene” to be a living, self-replicating unit of heredity. His postulation was adapted from Darwin’s “pangenesis”…
Fig. 1 A wet laboratory workflow for combining non-barcoded sample pooling and targeted re-sequencing Fig. 2 Overview of the bioinformatics MPS data analysis pipeline in targeted re-sequencing with pooled samples…
Fig. 1 Example experimental flowchart and data from a study utilizing laser capture microdissection and RNA-Seq. In this study, we exposed adult Fischer-344 rats either to their control home cage…
CHAPTER 4 Clinical Neuroanatomy I. Skull, Cerebrovascular Supply, and Venous Drainage Figure 4.1 Basal view of the skull highlighting the foramina. A. Foramina of the skull FORAMEN STRUCTURES Foramen cecum Vein to superior…
CHAPTER 12 Movement Disorders I. Definition A. Motor disorders are defined as a group of neurological disorders characterized by paucity of movement (hypokinesia), excessive movement (hyperkinesia), or sometimes a combination of both….
CHAPTER 21 Pediatric Neurology I. Embryology and Development A. Embryology of nervous system and corresponding disorders (high-yield items) 1. Risk factors for neural tube defects: maternal diabetes (caudal regression syndrome), folate deficiency and…
CHAPTER 28 Adult Psychiatry I. Psychochemistry A. Neurotransmitters 1. Dopamine (DA) a. Dopaminergic pathways b. Synthesis i. Tyrosine—(tyrosine hydroxylase) → L-dopa—(dopa decarboxylase) → DA ii. Tyrosine hydroxylase is the rate-limiting enzyme c. Catabolism i. DA is broken down by…
CHAPTER 10 Neuromuscular Disorders I. General Evaluation A. History 1. Chief complaint a. Weakness/motor versus sensory b. Acute versus subacute versus chronic c. Symmetric versus asymmetric 2. Contributing history a. Family history b. Medications, toxins c. Trauma d. Infections e. Vaccinations f. Diet…
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