The New Neuroembryology
The New Neuroembryology Harvey B. Sarnat Preformation is represented by DNA, not by … a tiny adult in every sperm. —Antonio García-Bellido, 1998 (1) Traditional embryology is descriptive morphogenesis: detailed…
NEUROLOGY
Chromosomal Anomalies and Contiguous-Gene Syndromes
Chromosomal Anomalies and Contiguous-Gene Syndromes John H. Menkes Rena E. Falk This chapter considers conditions that develop as a result of chromosomal abnormalities. Abnormalities of chromosomes are either constitutional or…
Heredodegenerative Diseases
Heredodegenerative Diseases John H. Menkes Advances in molecular biology have pointed to a basic similarity between diseases of metabolic origin (see Chapter 1) and heredodegenerative diseases. Nevertheless, essential differences remain….
Inherited Metabolic Diseases of the Nervous System
Inherited Metabolic Diseases of the Nervous System John H. Menkes William R. Wilcox The diseases considered in this chapter result from a single mutant gene that codes for an enzymatic…
Mitochondrial Encephalomyopathies
Mitochondrial Encephalomyopathies Harvey B. Sarnat John H. Menkes Mitochondrial disease may cause any symptom in any tissue at any age by any inheritance. —A. Munnich The above definition of mitochondrial…
Introduction: Neurologic Examination of the Child and Infant
Introduction: Neurologic Examination of the Child and Infant John H. Menkes Franklin G. Moser The ever-increasing sophistication and accuracy of neurodiagnostic procedures might cause younger physicians to view the neurologic…
Sudden Unexpected Death in Epilepsy
Chapter 15 Sudden Unexpected Death in Epilepsy FERGUS J. RUGG-GUNN, LINA. NASHEF Definition Epidemiology Risk Factors Demographics Epilepsy Characteristics Antiepileptic Medication Perimortem Features Other Features Pathophysiology of SUDEP Cerebrogenic Autonomic…
Pharmacodynamic Interactions of Antiepileptic Drugs
Chapter 18 Pharmacodynamic Interactions of Antiepileptic Drugs GAIL D. ANDERSON, JONG M. RHO Introduction Mechanisms of Actions of AEDs Pharmacodynamic Interactions Influencing Efficacy Pharmacodynamic Interactions Influencing Toxicity Antiepileptic Drug Polytherapy…
Does Early Treatment Influence the Long-Term Outcome of Epilepsy?
Chapter 17 Does Early Treatment Influence the Long-Term Outcome of Epilepsy? ANTHONY G. MARSON Seizure Recurrence following a First Seizure Seizure Recurrence following a Second Seizure Longer-Term Outcomes Assessing the…
Cortical Myoclonus and Epilepsy: Overlap and Differences
Chapter 8 Cortical Myoclonus and Epilepsy: Overlap and Differences RENZO. GUERRINI, FRANCESCO. MARI Introduction Cortical Myoclonus (CM) Epileptic Syndromes and Neurological Disorders with CM Epileptic Syndromes and Neurological Disorders with…
