White matter disorders
Figure 6.1 Axial fluid-attenuated inversion recovery (FLAIR) MRI scan of an older person with leukoaraiosis. Patchy white matter hyperintensties are scattered throughout the white matter. The concept of LA was…
Alzheimer’s Disease and white matter
Figure 14.1 Diagrams iIlustrating the gradual loss of white matter with aging. The left panel shows the trajectory of MRI frontal lobe white matter volume, and the right panel depicts…
Beyond corticocentrism
Figure 16.1 White matter dementia citations on PubMed before 1988 (211) and after (4,235). Since the idea of WMD was conceived, not only has the Human Connectome Project been vigorously…
Chronic traumatic encephalopathy and white matter
Figure 15.1 Postmortem coronal brain section showing diffuse axonal injury (DAI) in the corpus callosum after TBI (from Sharp DJ, Scott G, and Leech R, 2014). Neuroradiologists have endeavored to…
Therapeutic innovations
Figure 13.1 Simplified depiction of acquired factors implicated in the etiopathogenesis of two neurodegenerative diseases: Alzheimer’s Disease and chronic traumatic encephalopathy. Myelin repair The idea that myelin in the brain…
White matter and cognition: research perspectives
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> Chapter 12 White matter and cognition: research perspectives The prevailing view that cortical gray matter is the seat of higher functions has inspired a vast amount…
Treatment
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:mml=”http://www.w3.org/1998/Math/MathML” xmlns:epub=”http://www.idpf.org/2007/ops”> Chapter 11 Treatment The treatment of white matter dementia (WMD) and mild cognitive dysfunction (MCD) centers on the treatment of the underlying disorder deemed responsible for…
Mild cognitive dysfunction: a precursor syndrome
Figure 8.1 Proposed schematic relationship between white matter and cognition (WM – white matter, NAWM – normal-appearing white matter, MRI – magnetic resonance imaging). Distinction from mild cognitive impairment A…
White matter dementia
Figure 7.1 Axial T2-weighted MRI scan of a man with chronic toluene abuse and dementia. Arrows point out white matter hyperintensity, and there is also lateral ventricular enlargement (from Filley…
