Screening of New Compounds and the Role of the Pharmaceutical Industry H. Steve White Roger J. Porter Harvey J. Kupferberg Introduction The search for new antiepileptic drugs (AEDs) requires the…
Molecular Targets for Novel Antiepileptic Drugs Brian S. Meldrum Introduction The majority of antiepileptic drugs (AEDs) introduced since 1938 have been identified as anticonvulsants by means of screening tests using…
Basic Principles of Medicinal Chemistry Donald F. Weaver Raman Sankar Introduction Medicinal chemistry is the branch of applied organic chemistry that deals with the design and synthesis of new chemical…
Cellular Effects of Antiepileptic Drugs Robert L. MacDonald Michael A. Rogawski Introduction Antiepileptic drugs (AEDs) protect against seizures through interactions with a variety of cellular targets, which include various ion…
Overview: Antiepileptic Drugs Jacqueline A. French Elinor Ben-Menachem Introduction This section addresses pharmacologic treatment of the epilepsies. Despite the availability of other treatments, including surgery, various devices, and behavioral/homeopathic treatments,…
New Therapeutic Directions Robert S. Fisher Guy M. McKhann II John M. Stern Mark S. Quigg Jean Régis Donald L. Schomer Steven C. Schachter Annamaria Vezzani Introduction People with epilepsy,…
Complementary and Alternative Medical Therapies Steven C. Schachter Carlos Acevedo Keryma A. Acevedo Chi-Wan Lai Amadou G. Diop Introduction Despite the introduction of new antiepileptic drugs (AEDs), increasing use of…
Behavioral Therapies Peter Wolf To abolish this disease, one must apply the element which is opposed to it, and not what is favourable and habituated. On the Sacred Disease—Hippocrates Introduction…
Vagus Nerve Stimulation Steven C. Schachter Paul Boon Introduction For patients with medically refractory seizures, the major nonpharmacologic options are limited to epilepsy surgery, the ketogenic diet, and vagus nerve…
Sex-Hormone Treatment Andrew G. Herzog Introduction There is considerable scientific evidence at molecular biologic, neuronal, experimental animal, and clinical levels to indicate that reproductive steroids have neuroactive properties that play…
