Metastatic Tumors
Metastatic Tumors Enid Choi Graeme F. Woodworth Minesh P. Mehta INTRODUCTION It is estimated that 13.7 million people living in the United States today are alive with a diagnosis of…
Metabolic and Mitochondrial Myopathies in Adults
Metabolic and Mitochondrial Myopathies in Adults Michio Hirano Salvatore DiMauro Lewis P. Rowland INTRODUCTION Metabolic myopathies comprise a clinically and etiologically diverse group of disorders due to defects in cellular…
Stiff Person Syndrome and Peripheral Nerve and Muscle Hyperexcitability
Stiff Person Syndrome and Peripheral Nerve and Muscle Hyperexcitability Jonathan Perk Christina M. Ulane Lewis P. Rowland INTRODUCTION The terms muscle stiffness and cramps are used for commonly experienced symptoms…
Periodic Paralysis and Other Channelopathies
Periodic Paralysis and Other Channelopathies Comana M. Cioroiu Lewis P. Rowland INTRODUCTION Muscle channelopathies comprise a heterogeneous group of diseases of skeletal muscle that include both syndromes of episodic weakness…
Endocrine and Toxic Myopathies
Endocrine and Toxic Myopathies Christina M. Ulane INTRODUCTION Muscle comprises a large proportion of all tissues in the body and the energy required for its function renders it susceptible to…
Critical Illness Myopathy and Neuropathy
Critical Illness Myopathy and Neuropathy Michio Hirano Louis H. Weimer INTRODUCTION Although critically ill individuals in intensive care units are typically weak due to their severe medical illnesses, a subgroup…
Inflammatory Myopathies
Inflammatory Myopathies Rebecca Traub Christina M. Ulane Kurenai Tanji INTRODUCTION Myopathies, or disorders of skeletal muscle, are due to a variety of hereditary and acquired causes. Myopathies with genetic underpinnings…
Myasthenia Gravis and Disorders of the Neuromuscular Junction
Myasthenia Gravis and Disorders of the Neuromuscular Junction Christina M. Ulane Lewis P. Rowland INTRODUCTION Pathology at the neuromuscular junction can occur at the presynaptic or postsynaptic membrane. Autoimmune disorders,…
Acquired Peripheral Neuropathies
Acquired Peripheral Neuropathies Thomas H. Brannagan III Kurenai Tanji APPROACH TO PERIPHERAL NERVE DISORDERS The peripheral nervous system is composed of multiple cell types and elements that subserve diverse motor,…
