Inherited Peripheral Neuropathies Chiara Pisciotta Michael E. Shy INTRODUCTION Inherited neuropathies, collectively known as Charcot-Marie-Tooth (CMT) disease, are a group of genetically and phenotypically heterogeneous peripheral neuropathies associated with mutations…
Bell Palsy and Cranial Neuropathies Comana M. Cioroiu Thomas H. Brannagan III Isolated cranial neuropathies are not uncommon, the most frequently encountered of which is Bell palsy. These syndromes can…
Amyotrophic Lateral Sclerosis and Motor Neuron Diseases Rebecca Traub Hiroshi Mitsumoto INTRODUCTION Several different diseases are characterized by progressive degeneration and loss of motor neurons in the spinal cord with…
Parkinson-Plus Syndromes Paul Greene INTRODUCTION Parkinson disease (PD) is the most common cause for a dopamine deficiency syndrome, but other causes for this syndrome had been identified from a small…
Parkinson Disease Stanley Fahn Un Jung Kang INTRODUCTION In 1817, James Parkinson described the major clinical motor features of what today is recognized as the symptom complex known as parkinsonism,…
Huntington Disease Karen S. Marder INTRODUCTION Huntington disease (HD) is an autosomal dominant neurodegenerative disorder caused by a cytosine-adenine-guanine (CAG) polyglutamine repeat expansion in exon 1 of the Huntington (HTT)…
Tardive Dyskinesia and Other Neuroleptic-Induced Syndromes Un Jung Kang Robert E. Burke Stanley Fahn INTRODUCTION Antipsychotic drugs are commonly called neuroleptics because they often induce parkinsonism. They also cause other…
Hereditary and Acquired Ataxias Rachel Saunders-Pullman Susan B. Bressman Roger N. Rosenberg INTRODUCTION Ataxia is characterized by incoordination, and herein we describe ataxias that are due to lesions in the…
