History Herman Schloffer, according to Liu et al, performed the first successful modern transsphenoidal approach for a pituitary tumor in March of 1907. It was a tedious three-stage procedure, with…

Introduction Pituitary metastases are an uncommon manifestation of systemic cancer and usually a marker of terminal disease. With improved survival for various types of cancer and with the use of…

Introduction Since the repopularization of the transsphenoidal approach by Guiot and Hardy, most surgeons have adopted this technique as the primary method for the removal of pituitary adenomas. Following the…

Introduction Tumors of the pituitary gland and sellar region represent approximately 10% to 15% of all brain tumors. Several types of tumors may involve the sellar region, reflecting its complex…

Introduction The transsphenoidal route is a direct and rapid extracerebral approach to the sellar region and therefore it is the most widely used technique for the processes involving this area….

Introduction Prolactin-secreting adenomas or prolactinomas constitute the largest group of pituitary adenomas in an autopsy series. They are responsible for approximately 27% of pituitary tumors. In the advent of medical…

Introduction Intraoperative imaging has played a substantial role in the history of transsphenoidal surgery. Cushing’s discontinued his use of transnasal pituitary surgery mainly because of limited visibility during the operation….

Introduction Cushing’s syndrome is an endocrinopathy, resulting in distinctive clinical features and associated systemic changes. Cushing’s disease is the name given to the disorder when it is caused by a…

Introduction Radiotherapy has been successfully used for many decades to control tumor growth and hormonal hypersecretion of pituitary adenomas. Although initially used as a primary treatment for these neoplasms, in…

Introduction Primary pituitary carcinomas are rare tumors defined as primary adenohypophyseal neoplasms that have undergone cerebrospinal or systemic metastasis. They constitute 0.1% to 0.2% of all pituitary tumors and their…