NEUROLOGY

Role of Stemness Factors in Neuroblastoma: Neuroblastoma Stem Cells, Tumor Microenvironment, and Chemoresistance

Apr 6, 2019 by in NEUROLOGY Comments Off on Role of Stemness Factors in Neuroblastoma: Neuroblastoma Stem Cells, Tumor Microenvironment, and Chemoresistance

Abstract The cancer stem cell paradigm is the idea that subpopulations of cancer cells exist within a tumor that are capable of self-renewal, multipotency, proliferation, and tumor maintenance. This subpopulation…

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Energy Metabolism and Metabolic Targeting of Neuroblastoma

Apr 6, 2019 by in NEUROLOGY Comments Off on Energy Metabolism and Metabolic Targeting of Neuroblastoma

Abstract Energy metabolism refers to all the reactions involved in generating adenosine triphosphate (ATP) from nutrients, including both aerobic respiration (oxygen present), anaerobic respiration (fermentation) as well as fatty acid…

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Neuroblastoma Pathology and Classification for Precision Prognosis and Therapy Stratification

Apr 6, 2019 by in NEUROLOGY Comments Off on Neuroblastoma Pathology and Classification for Precision Prognosis and Therapy Stratification

Abstract Tumors in neuroblastoma group offer one of the best models for investigating the biologically significant relationship between their genetic/molecular properties and morphologic manifestations. Over the past decades, histopathological analysis…

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GD2-Targeted Immunotherapy of Neuroblastoma

Apr 6, 2019 by in NEUROLOGY Comments Off on GD2-Targeted Immunotherapy of Neuroblastoma

Abstract Disialoganglioside GD2 is highly expressed on neuroectodermal tumors and sarcomas, but only weakly expressed on limited normal tissues. It has been identified as a marker for a subset of…

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Transcranial Doppler Ultrasonography

Apr 6, 2019 by in NEUROLOGY Comments Off on Transcranial Doppler Ultrasonography

Abstract Monitoring the cerebral blood flow (CBF) is critical in patients with known neurological disease as well as in patients at risk of neurological damage in the perioperative period. Transcranial…

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Near-Infrared Spectroscopy

Apr 6, 2019 by in NEUROLOGY Comments Off on Near-Infrared Spectroscopy

Abstract Near-infrared spectroscopy (NIRS) is an emerging noninvasive monitoring modality based on chromophore absorption of infrared light. There are four different types of NIRS system—continuous, time domain, frequency domain, and…

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Functional MR Imaging

Apr 6, 2019 by in NEUROLOGY Comments Off on Functional MR Imaging

Abstract The scientific basis of functional imaging is the change in cerebral metabolism and cerebral blood flow associated with neurological function in the brain. Functional imaging is based on imaging…

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