Fig. 9.1 Neurogenesis in the SVZ. (a) Schematic brain sagittal section showing the two main neurogenic niches in the postnatal brain, the dentate gyrus of the hippocampus and the SVZ…
Fig. 5.1 Microtubule biology and cellular function. (a) Tubulin heterodimers are the basic building units of microtubules. Both isoforms can bind to a guanidine nucleotide. Whereas α-tubulin cannot hydrolyze and…
Fig. 4.1 Cortical layering process in mouse embryos. Half coronal section through the forebrain of an E14.5 mouse embryo (upper left scheme). Successive waves of post-mitotic projection neurons are generated…
Fig. 1.1 Developmental sequence of inside-out cortical layer assembly. During cortical layer formation, earlier born neurons occupy lower layers and later born neurons progressively occupy upper layers. In the developing…
Fig. 7.1 Germinal zone migration in the developing cerebellum. (a) Cerebellar granule neuron precursors (cGNPs) migrate tangentially (horizontal arrows) within the External Granule Layer (EGL). They then transition to a…
Fig. 8.1 The function of transcription factors in spinal motor neuron migration. Summary of expression of LIM homeodomain and Hox transcription factors in spinal motor neuron subpopulations (a). Functional evidence…
Fig. 2.1 Proliferation of neuronal stem cells and interkinetic nuclear migration Intermediate progenitor (IP) cells reside within the VZ and often divide at ventricular surface at early stages of neurogenesis…
Fig. 6.1 MARK/Par-1 domains and major modes of regulation. MARK/Par-1 kinases consist of an N-terminal domain (N) a catalytic domain followed by a common docking domain-like CD-like motif, an auto-regulatory…
Fig. 3.1 Scheme of the JNK cascade and the upstream components that regulate cell migration during cortical development. (a) JNKs are the effector kinases that reside at the end of…
