© Springer International Publishing AG 2017Jennifer Moliterno Gunel, Joseph M Piepmeier and Joachim M. Baehring (eds.)Malignant Brain Tumors 10.1007/978-3-319-49864-5_17 17. Tumor-Specific Approach: Oligodendroglioma (IDH1 Mutated, 1p/19q Deleted) Charles Marc Leyrer1 , Erin Murphy1 and Manmeet Ahluwalia2 (1) 9500 Euclid Ave./T-28, Cleveland,…
Fig. 16.1 Schematic overview of a possible clinical decision algorithm outside clinical trials for infiltrative glioma. IDH isocitrate dehydrogenase; ATRX alpha thalassemia mental retardation X-linked; MGMT O6 methylguanine methyltransferase; G–CIMP glioma-CpG…
© Springer International Publishing AG 2017Jennifer Moliterno Gunel, Joseph M Piepmeier and Joachim M. Baehring (eds.)Malignant Brain Tumors 10.1007/978-3-319-49864-5_15 15. Glioma Radiosensitizers: Exciting New Developments and Directions Christopher D. Corso1 and Ranjit S. Bindra1 (1) Department of Therapeutic Radiology, Yale…
Carrier Treatment Phase Study population # of patients Results Reference Nanoparticles Aminosilane-coated iron oxide particles and alternating magnetic fields I Recurrent grade IV astrocytoma 14 • Minor or no side…
Fig. 5.1 Illustrative case of a 50 years-old frustrated left-handed patient diagnosed with a left frontal glioblastoma revealed by headaches and language disturbances. a Preoperative T1-gadolinium enhanced MRI, showing a large enhancing…
Trial Phase Disease type Patients (n) Arms Median PFS (mo) PFS-6 (%) Median OS (mo) Reference BRAIN 2 rGBM 167 BEV 4.2 42.6 9.2 [37] BEV + irinotecan 5.6 50.3 8.7 NCI 2 rGBM 48 BEV…
Fig. 9.1 Critical signaling pathways altered in malignant gliomas. Primary sequence alterations and significant copy number changes for the components of the a | RTK/RAS/PI3K, b | p53, and c |…
Fig. 8.1 a Magnetic resonance imaging of brain—glioblastoma magnetic resonance imaging reveals the aggressive nature of glioblastoma with the typical ring enhancement, central necrosis, and significant mass effect. b Magnetic resonance…
