Abstract The potent neuroprotective properties of N -methyl-d-aspartate (NMDA) antagonists have been well established in experimental models of neurological insults in which excitotoxicity is contributory. However, early clinical trials using…
Abstract Mood disorders secondary to traumatic brain injury (TBI) are a relatively common phenomenon. Having a strong understanding of the risk factors, diagnostic procedures, and currently available treatments strengthens clinicians’…
Abstract Administration of omega 3 polyunsaturated fatty acids (n-3 PUFAs) is a biologically plausible, yet clinically untested, candidate therapeutic strategy to prevent or blunt neurologic disability after traumatic brain injury…
Abstract As it is increasingly clear that traumatic brain injury (TBI) leads to cognitive problems, particularly posttraumatic memory and attention difficulties at different levels of severity ( ), leading to…
Abstract Reactive oxygen-induced lipid peroxidation (LP) has been documented to play a critical role in pathophysiology, neurodegeneration, and neurological disability that follows acute traumatic brain injury (TBI) and spinal cord…
Abstract Traumatic brain injury (TBI) leads to excess glutamate release from dead and dying neurons, and consequently to secondary neuronal damage weeks and months after initial injury. The GLT-1 (EAAT2…
Abstract Traumatic brain injury (TBI) is a major health problem worldwide. Following the primary injury, there is no cure to rescue the damaged neural tissue. Current treatment options for TBI…
Abstract It is known that estrogen can mitigate neurological injury. However, to optimize estrogen’s benefits, it must be administered as soon as possible postinjury, preferably within the “golden hour.” We…
Abstract As part of the innate immune response, leukotrienes initiate the first line of defense against tissue damage. They also play key pathological roles in chronic inflammatory diseases like asthma….
Abstract Traumatic brain injury (TBI) is a leading cause of death and disability in the United States, and, to date, no pharmacological agents are known to improve neurological outcome following…
