How to Render Neural Fields More Realistic
-molecules, study the properties of the atoms and the inter-molecule interactions like hydrogen bridges and van-der-Waals bounds. Now, to describe a water wave, one has to study millions and millions…
Modelling Cortical and Thalamocortical Synaptic Loss and Compensation Mechanisms in Alzheimer’s Disease
Fig. 9.1 Connectivity of the network model, reproduced with permission from [68] The cortical model and the cortical part of the thalamocortical model is inspired by the anatomy of the…
Discovery and Validation of Biomarkers Based on Computational Models of Normal and Pathological Hippocampal Rhythms
accumulation. This can help elucidate a mechanism of age-dependent theta oscillation changes in AD mouse models, reflecting changes in synchronous synaptic activity that could mediate oscillation-dependent memory deficiencies and serve…
DCM, Conductance Based Models and Clinical Applications
. In neural systems, these parameters usually correspond to time constants or synaptic strengths of the connections between the system elements. The mathematical form of the dependencies and the pattern…
Toward Networks from Spikes
to indicate the set of all event pairs wherein an event on neuron A precedes an event on neuron B by time . These sets are sometimes referred to as…
Computational Modeling of Neuronal Dysfunction at Molecular Level Validates the Role of Single Neurons in Circuit Functions in Cerebellum Granular Layer
Fig. 8.1 Schematic representation of cerebellar circuits. At the sub-cortical levels, afferent fibers carrying sensory information activate the deep cerebellar nuclei and inferior olive cells. In the cerebellar cortex, there…
Epileptogenic Networks: Applying Network Analysis Techniques to Human Seizure Activity
(1) where E is the expected values operator and τ is the offset, or time lag. To define a network, we define each microelectrode in the MEA as a node,…
Introduction
(1.1) Where V represents the membrane potential, C represents the membrane capacitance, g m —the conductance of a particular ion-channel, V m is this ion’s reversal potential and I(t) represents…
Multilevel Computational Modelling in Epilepsy: Classical Studies and Recent Advances
Fig. 7.1 Schematic representation of spatial and temporal scales relevant in epilepsy and seizures. (a–b) Consider the activity of a single neuron generating a spike-train. (c–e) Consider a network of…
Palatal Surgery
, Wolfgang Pirsig2 and Joachim T. Maurer3 (1) Department of Otorhinolaryngology Head and Neck Surgery, Asklepios Clinic Harburg, Eissendorfer Pferdeweg 52, 21075 Hamburg, Germany (2) Department of Otorhinolaryngology Head and Neck Surgery, Mozartstrasse 22/1,…
