Fig. 7.1 Immunohistochemical localization of islet cell hormones in normal islets. (a) Insulin localization in approximately 60–70 % of islet cells. (b) Glucagon localization in the periphery of the islets…
Fig. 3.1 Comparison between 18F-FDG PET/CT and 68Ga-DOTANOC PET/CT in a patient with a nodule in the pancreatic tail incidentally detected at CT. 18F-FDG PET/CT showed no 18F-FDG uptake in…
Fig. 16.1 Clear cell (lipid-rich) variant of pancreatic neuroendocrine tumor in (a). Oncocytic variant of pancreatic nonfunctioning neuroendocrine tumor in (b) Among prognostically relevant histologic findings, there are vascular invasion…
Fig. 10.1 Functioning somatostatinoma characterized by a trabecular architecture (a) and showing somatostatin (b) and calcitonin (c) immunoreactivity (H original magnification ×400; immunohistochemistry original magnification ×200) Fig. 10.2 Nonfunctioning somatostatin-producing…
Fig. 1.1 (a) Paul Langerhans (1847–1888) in 1873 (© Bildarchiv Preußischer Kulturbesitz, Berlin, 1873, Photographer: Ruf und Dilger [85]) (b) Histological appearance of the islet of Langerhans (hematoxylin-eosin) In 1893,…
Fig. 22.1 Approved and not approved therapies in NENs. IFN interferon, PRRT peptide radioreceptor therapy 22.2 General Approach Therapeutic approach can change according to the functioning/nonfunctioning status of the neoplasm….
© Springer International Publishing Switzerland 2015Stefano La Rosa and Fausto Sessa (eds.)Pancreatic Neuroendocrine Neoplasms10.1007/978-3-319-17235-4_21 21. Surgical Therapy of Pancreatic Neuroendocrine Neoplasms Angela Maurizi1 , Stefano Partelli2, Francesca Muffatti2, Sara Nobile2 and Massimo Falconi2 (1) Department of Surgery, Università Politecnica delle Marche,…
Fig. 12.1 Histology of a gastrinoma. Left: H&E, 20×. Right: Immunohistochemical staining for gastrin, 20× 12.5 Determination of the Site of Origin and Therapy Surgery is the only curative treatment…
Syndrome Affected gene Prevalence in PanNETs (%) Multiple endocrine neoplasia type 1 MEN1 20–70 Von Hippel-Lindau VHL <20 Neurofibromatosis type 1 NF1 <10 Tuberous sclerosis complex TSC2 Rare (~1) MEN1…
© Springer International Publishing Switzerland 2015Stefano La Rosa and Fausto Sessa (eds.)Pancreatic Neuroendocrine Neoplasms10.1007/978-3-319-17235-4_4 4. Endocrinological Approach to the Diagnosis of Pancreatic Neuroendocrine Neoplasms Wouter W. de Herder1 (1) Department of Internal Medicine, Section of Endocrinology, Erasmus MC,…
