Abstract The major neuropathological substrate of human preterm brain injury is the encephalopathy of prematurity, a term coined to characterize the multifaceted gray and white matter lesions in the preterm…
Abstract Hypoxic-ischemic brain injury is a very important neurological problem of the perinatal period. This importance of hypoxic-ischemic brain injury relates to the general gravity of the lesions and to…
Abstract The neuropathology of the encephalopathy of prematurity (see Chapter 14 ) includes injury to cerebral white matter and, in a major proportion of infants, a variety of neuronal-axonal disturbances….
Abstract As progenitor cells proliferate and differentiate into neurons and glia (see Chapter 5 ), these cells migrate to form the cerebral cortex in an elaborate and still not completely…
The neurological evaluation of the newborn comprises, as it does at other ages in pediatric medicine, the history, physical examination, and appropriate specialized studies. Appropriate neurodevelopmental follow-up is the critical…
Abstract This chapter addresses the pathophysiology of hypoxic-ischemic injury. The neuropathology of this injury includes three principal lesions: selective neuronal necrosis, parasagittal cerebral injury, and cerebral white matter injury. Several…
Abstract The awesome complexity of the human brain begins its evolution after the essential external form is established by the events described in Chapters 1 and 2 . The events…
Abstract Myelination is characterized by the acquisition of the highly specialized myelin membrane around axons. It begins before birth within the caudal brain stem and progresses rostrally to the forebrain,…
Abstract Neurodevelopmental follow-up is a critical component of the evaluation of the neurological development and ongoing clinical needs of the high-risk newborn. Such follow-up is important because it has become…
Abstract The prosencephalon develops at the rostral end of the recently closed neural tube, starting early in the second month of gestation. Through a series of cleavages, the prosencephalon develops…
