Chemotherapy
11. Therasse P, Arback SG, Eisenhauer EA et al (2000) New guidelines to evaluate the response to treatment in solid tumors: European Organization for Research and Treatment of Cancer (EORTC),…
Somatostatin Analogs and Interferon in the Treatment of Neuroendocrine Tumors
© Springer-Verlag Berlin Heidelberg 2015Suayib Yalcin and Kjell Öberg (eds.)Neuroendocrine Tumours10.1007/978-3-662-45215-8_30 30. Somatostatin Analogs and Interferon in the Treatment of Neuroendocrine Tumors Jonathan Strosberg1 (1) Neuroendocrine Tumor Program, H. Lee Moffitt Cancer Center and Research Institute,…
Carcinoid Syndrome
Symptom Frequency (%) Flushing 85 Telangiectasia 25 Cyanosis 18 Pellagra 2–25 Diarrhea 75–80 Abdominal cramp 75 Bronchospasm 20 Valvular lesions 50 Right heart 40 Left heart 13 Asthenia <5 Neuropsychiatric…
Management of Hormonal Symptoms
Tumor type Oversecretion of main substances Clinical syndromes All NENs CgA Carcinoid Serotonin Carcinoid syndrome Insulinoma Insulin, C peptide or proinsulin Hypoglycemia and neuroglycopenia Gastrinoma Gastrin Zollinger-Ellison syndrome (ZES) Glucagonoma…
Medullary Thyroid Cancer
Frequency (%) Features of MTC Associated diseases Sporadic MTC 70 Unifocal MEN-2A 20 Autosomal dominant Multifocal, bilateral Pheochromocytoma Primary parathyroid hyperplasia Cutaneous lichen planus amyloidosis (rare) Hirschsprung disease (rare)…
Diagnosis and Management of Adrenocortical Carcinomas
Stage Macfarlane [43] Lee et al. [45] I T1 (<5 cm) N0M0 T1 (<5 cm) N0M0 II T2 (>5 cm) N0M0 T2 (>5 cm) N0M0 III T3 (local invasion without…
Nonfunctioning Pancreatic Neuroendocrine Tumors
ENETS TNM UICC/AJCC/WHO 2010 TNM T classification Limited to the pancreas, <2 cm Limited to the pancreas, ≤2 cm in greatest dimension Limited to the pancreas, 2–4 cm Limited to…
Less Common Types of Pancreatic Neuroendocrine Tumors
Name Biologically active peptide(s) secreted Incidence Tumor location Malignant % Associated with MEN-1, % Main symptoms/signs ACTHoma ACTH Rare Pancreas >95 Rare Cushing’s syndrome (100 %) CRHoma, Corticotropin-releasing hormone Rare…
Insulinoma
12.3.1 Reactive “Functional Hypoglycemia” Reactive “functional hypoglycemia” is a controversial entity, and it is now known that many organic disorders may result both in fasting and/or reactive hypoglycemia. Many patients…
Nuclear Medicine Imaging in Neuroendocrine Tumors
Name SST1 SST2 SST3 SST4 SST5 Ga-DOTATATE >10,000 0.2 ± 0.04 >10,000 300 ± 140 377 ± 18 Ga-DOTATOC >10,000 2.5 ± 0.5 613 ± 140 >1,000 73 ± 21 Ga-DOTANOC >10,000 1.9 ± 0.4 40 ± 5.8 260 ± 74 7.2 ± 1.6 Data from Refs. [15, 16] SST…
